J
John P. Iredale
Researcher at University of Bristol
Publications - 221
Citations - 26200
John P. Iredale is an academic researcher from University of Bristol. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 77, co-authored 221 publications receiving 23394 citations. Previous affiliations of John P. Iredale include University College London & University of Cambridge.
Papers
More filters
Journal ArticleDOI
An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias.
Ruairi Lynch,Catherine A. Hawley,Antonella Pellicoro,Calum C. Bain,John P. Iredale,Stephen J. Jenkins +5 more
TL;DR: It is shown that conventional flow‐cytometric strategies for identification of Kupffer cells (KCs) leads to inclusion of a significant proportion of CD31hi endothelial cells, which represent endothelium tightly adhered to remnants of KC membrane.
Journal ArticleDOI
Hepatocyte-matrix interactions.
TL;DR: There is now evidence that the basement membrane-like matrix of the liver can change the phenotypic characteristics and growth of lipocytes, endothelial cells, and hepatocytes.
Journal ArticleDOI
Galectin-3 regulates hepatic progenitor cell expansion during liver injury
Wei Chen Hsieh,Alison C. MacKinnon,Wei-Yu Lu,Jonathan Jung,Luke Boulter,Neil C. Henderson,Kenneth J. Simpson,Baukje Schotanus,Davina Wojtacha,Thomas G. Bird,Claire N. Medine,David C. Hay,Tariq Sethi,John P. Iredale,Stuart J. Forbes +14 more
TL;DR: It is concluded that Gal-3 is required for the undifferentiated expansion of HPCs in their niche in injured liver.
Journal ArticleDOI
Familial and idiopathic colonic varices: an unusual cause of lower gastrointestinal haemorrhage.
TL;DR: A patient is described presenting with an acute lower gastrointestinal haemorrhage as a result of extensive colonic varices, and further investigation revealed that there were no oesophageal varices or splenomegaly.
Journal ArticleDOI
Impaired Proteolysis of Collagen I Inhibits Proliferation of Hepatic Stellate Cells IMPLICATIONS FOR REGULATION OF LIVER FIBROSIS
Xiaoying Zhou,Aqeel Jamil,Andrew Nash,James Chan,Nathan Trim,John P. Iredale,R. Christopher Benyon +6 more
TL;DR: In this article, the role of pericellular collagen I proteolysis in both regulating proliferation and maintaining the activated myofibroblastic phenotype of stellate cells in vitro was investigated.