J
John P. Zimmer
Researcher at Massachusetts Institute of Technology
Publications - 17
Citations - 3488
John P. Zimmer is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Quantum dot & Luminescence. The author has an hindex of 15, co-authored 17 publications receiving 3386 citations.
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Journal ArticleDOI
A Ratiometric CdSe/ZnS Nanocrystal pH Sensor
Preston T. Snee,Rebecca C. Somers,Gautham Nair,John P. Zimmer,Moungi G. Bawendi,Daniel G. Nocera +5 more
TL;DR: The development of a reversible chemical sensor based on a CdSe/ZnS nanocrystal (NC) results in a ratiometric sensor since the emission intensities of dye and NC may be referenced to the isosbestic point between NC and dye emissions.
Journal ArticleDOI
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
Mark Stroh,John P. Zimmer,Dan G. Duda,Tatyana S. Levchenko,Kenneth S. Cohen,Edward B. Brown,David T. Scadden,Vladimir P. Torchilin,Moungi G. Bawendi,Dai Fukumura,Rakesh K. Jain +10 more
TL;DR: Fluorescent semiconductor nanocrystals can be customized to concurrently image and differentiate tumor vessels from both the perivascular cells and the matrix and monitored the recruitment of quantum dot–labeled bone marrow–derived precursor cells to the tumor vasculature.
Journal ArticleDOI
Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.
John P. Zimmer,Sang-Wook Kim,Shunsuke Ohnishi,Eichii Tanaka,John V. Frangioni,Moungi G. Bawendi +5 more
TL;DR: A size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature.
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Blue Luminescence from (CdS)ZnS Core–Shell Nanocrystals
Jonathan S. Steckel,John P. Zimmer,Seth Coe-Sullivan,Nathan E. Stott,Vladimir Bulovic,Moungi G. Bawendi +5 more
Journal ArticleDOI
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Trevor D. McKee,Paola Grandi,Wilson Mok,Wilson Mok,George Alexandrakis,Numpon Insin,John P. Zimmer,Moungi G. Bawendi,Yves Boucher,Xandra O. Breakefield,Rakesh K. Jain +10 more
TL;DR: Fibrillar collagen can be a formidable barrier to viral distribution and matrix-modifying treatments can significantly enhance the therapeutic response, resulting in an extended range of infected tumor cells and improved virus propagation, ultimately leading to enhanced therapeutic outcome.