J
John S. Beech
Researcher at University of Oxford
Publications - 58
Citations - 2440
John S. Beech is an academic researcher from University of Oxford. The author has contributed to research in topics: Intracellular pH & Lesion. The author has an hindex of 25, co-authored 58 publications receiving 2240 citations. Previous affiliations of John S. Beech include University of Cambridge & King's College London.
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Journal ArticleDOI
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors
Patryk Moskwa,Francesca M. Buffa,Yunfeng Pan,Rohit A. Panchakshari,Ponnari Gottipati,Ruth J. Muschel,John S. Beech,Ritu Kulshrestha,Kotb Abdelmohsen,David M. Weinstock,Myriam Gorospe,Adrian L. Harris,Thomas Helleday,Thomas Helleday,Thomas Helleday,Dipanjan Chowdhury +15 more
TL;DR: It is suggested that miR-182-mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy.
Journal ArticleDOI
Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells
TL;DR: MHP36 cells may improve functional outcome after MCAO by assisting spontaneous reorganization in both the damaged and intact hemispheres.
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Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis*‡§
Lei Zhao,Su Yin Lim,Alex Gordon-Weeks,Thomas T. Tapmeier,Jae Hong Im,Yunhong Cao,John S. Beech,Danny Allen,Sean Smart,Ruth J. Muschel +9 more
TL;DR: These findings highlight the importance of myeloid cells—in this case a selective CD11b/Gr1mid subset—in sustaining development of colorectal cancer liver metastasis and identify a potential target for antimetastatic therapy.
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Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature
Emmanouil Fokas,Jae Hong Im,Sarah C. Hill,Sabira Yameen,Michael R.L. Stratford,John S. Beech,Wolfgang Hackl,Sauveur-Michel Maira,Eric J. Bernhard,W. Gillies McKenna,Ruth J. Muschel +10 more
TL;DR: It is shown that NVP-BEZ235, a dual inhibitor of phosphoinositide-3-kinase (PI3K) and mTOR, can improve tumor oxygenation and vascular structure over a prolonged period that achieves the aim of effective vascular normalization.
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A chronic 1 year assessment of MRI contrast agent-labelled neural stem cell transplants in stroke.
TL;DR: The translation of cellular imaging does not only require the in vitro assessment of contrast agents on cellular functions, but also requires the chronic, in vivo assessment of the label on the stem cells' ability to repair in preclinical models of neurological disease.