Y
Yunfeng Pan
Researcher at Harvard University
Publications - 18
Citations - 2394
Yunfeng Pan is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Homologous recombination. The author has an hindex of 10, co-authored 12 publications receiving 2105 citations. Previous affiliations of Yunfeng Pan include Helmholtz-Zentrum Dresden-Rossendorf.
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Journal ArticleDOI
DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta,Neil J. Ganem,Neil J. Ganem,Regina Dagher,Regina Dagher,Alexandra B. Lantermann,Elena Ivanova,Yunfeng Pan,Luigi Nezi,Alexei Protopopov,Dipanjan Chowdhury,David Pellman,David Pellman +12 more
TL;DR: A mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei is identified, which potentially lead to mutations and chromosome rearrangements that can integrate into the genome.
Journal ArticleDOI
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors
Patryk Moskwa,Francesca M. Buffa,Yunfeng Pan,Rohit A. Panchakshari,Ponnari Gottipati,Ruth J. Muschel,John S. Beech,Ritu Kulshrestha,Kotb Abdelmohsen,David M. Weinstock,Myriam Gorospe,Adrian L. Harris,Thomas Helleday,Thomas Helleday,Thomas Helleday,Dipanjan Chowdhury +15 more
TL;DR: It is suggested that miR-182-mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy.
Journal ArticleDOI
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.
Ashish Lal,Yunfeng Pan,Francisco Navarro,Derek M. Dykxhoorn,Lisa A. Moreau,Eti Meire,Zvi Bentwich,Judy Lieberman,Dipanjan Chowdhury +8 more
TL;DR: It is found that miR-24 is upregulated during postmitotic differentiation of hematopoietic cell lines and regulates the histone variant H2AX, a protein that has a key role in the double-stranded break response.
Journal ArticleDOI
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
TL;DR: It is shown that human protein phosphatase 4 (PP4) dephosphorylates replication protein A (RPA) subunit RPA2, regulating its role in the DSB response, and new insight is provided into the role and regulation of RPA phosphorylation in HR-mediated repair.
Journal ArticleDOI
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response
Dong-Hyun Lee,Aaron A. Goodarzi,Guillaume Adelmant,Yunfeng Pan,Penny A. Jeggo,Jarrod A. Marto,Dipanjan Chowdhury +6 more
TL;DR: A new role for PP4‐mediated dephosphorylation in the DDR is identified by showing that phosphorylation of S473 impacts the G2/M checkpoint, and the regulation of a previously undescribed function of KAP‐1 in checkpoint response is identified.