R
Rohit A. Panchakshari
Researcher at Takeda Pharmaceutical Company
Publications - 12
Citations - 1134
Rohit A. Panchakshari is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Immunoglobulin class switching & Intestinal epithelium. The author has an hindex of 8, co-authored 11 publications receiving 961 citations. Previous affiliations of Rohit A. Panchakshari include Harvard University & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors
Patryk Moskwa,Francesca M. Buffa,Yunfeng Pan,Rohit A. Panchakshari,Ponnari Gottipati,Ruth J. Muschel,John S. Beech,Ritu Kulshrestha,Kotb Abdelmohsen,David M. Weinstock,Myriam Gorospe,Adrian L. Harris,Thomas Helleday,Thomas Helleday,Thomas Helleday,Dipanjan Chowdhury +15 more
TL;DR: It is suggested that miR-182-mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy.
Journal ArticleDOI
Microbial colonization influences early B-lineage development in the gut lamina propria
Duane R. Wesemann,Andrew J. Portuguese,Andrew J. Portuguese,Andrew J. Portuguese,Robin M. Meyers,Robin M. Meyers,Robin M. Meyers,Michael P. Gallagher,Michael P. Gallagher,Michael P. Gallagher,Kendra Cluff-Jones,Kendra Cluff-Jones,Kendra Cluff-Jones,Jennifer M. Magee,Jennifer M. Magee,Jennifer M. Magee,Rohit A. Panchakshari,Rohit A. Panchakshari,Rohit A. Panchakshari,Scott J. Rodig,Thomas B. Kepler,Frederick W. Alt,Frederick W. Alt,Frederick W. Alt +23 more
TL;DR: It is reported that early B-cell development also occurs within the mouse intestinal lamina propria (LP), where the associated V(D)J recombination/receptor editing processes modulate primary LP immunoglobulin repertoires.
Journal ArticleDOI
Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing
Jiazhi Hu,Robin M. Meyers,Junchao Dong,Rohit A. Panchakshari,Frederick W. Alt,Frederick W. Alt,Richard L. Frock +6 more
TL;DR: LAM-HTGTS assays are sensitive, reproducible, relatively inexpensive, scalable and straightforward to implement with a turnaround time of <1 week, and differs from related approaches because it detects a wide range of broken end structures with nucleotide-level resolution.
Journal ArticleDOI
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching
Junchao Dong,Rohit A. Panchakshari,Tingting Zhang,Yu Zhang,Jiazhi Hu,Sabrina A. Volpi,Robin M. Meyers,Yu-Jui Ho,Zhou Du,Davide F. Robbiani,Fei-Long Meng,Monica Gostissa,Michel C. Nussenzweig,John P. Manis,Frederick W. Alt +14 more
TL;DR: CSR is programmed to occur in a productive deletional orientation and does so via an unprecedented mechanism that involves in cis Igh organizational features in combination with frequent S-region DSBs initiated by AID, and is implicate ATM-dependent DSB-response factors in enforcing this mechanism.
Journal ArticleDOI
Translational Control of TOP2A Influences Doxorubicin Efficacy
Subramanya Srikantan,Kotb Abdelmohsen,Eun Kyung Lee,Kumiko Tominaga,Sarah S. Subaran,Yuki Kuwano,Ritu Kulshrestha,Rohit A. Panchakshari,Hyeon Ho Kim,Hyeon Ho Kim,Xiaoling Yang,Jennifer L. Martindale,Bernard S. Marasa,Mihee M. Kim,Robert P. Wersto,Fred E. Indig,Dipanjan Chowdhury,Myriam Gorospe +17 more
TL;DR: It is reported that the RNA-binding protein HuR, commonly overexpressed in cancers, binds to the TOP2A 3′-untranslated region (3′UTR) and increases Top 2A translation by competing with miR-548c-3p; their combined actions control TOP 2A expression levels and determine the effectiveness of doxorubicin.