John S. Tregoning

TL;DR: In this review, the complete picture from epidemiology and virology to clinical impact and immunology is explored, finding that both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.

TL;DR: A snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern are provided in this paper, where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease.

TL;DR: Animal models of immune enhancement permit a deep understanding of the role of specific immune responses in RSV disease, assist in vaccine design, and indicate which immunomodulatory therapy might be beneficial to children with bronchiolitis.

TL;DR: In this paper, the authors compared synthetic mRNA and sa-RNA expressing influenza virus hemagglutinin, and concluded that saRNA is a promising platform for vaccines against viral diseases.

TL;DR: Exercise of TetC in chloroplasts provides a potential route towards the development of a safe, plant-based tetanus vaccine for nasal and oral applications and proves the versatility of plastids for expression of unmodified high-AT and high-GC genes.