J
Jürgen Schwarze
Researcher at University of Edinburgh
Publications - 142
Citations - 9293
Jürgen Schwarze is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 45, co-authored 130 publications receiving 7719 citations. Previous affiliations of Jürgen Schwarze include Ruhr University Bochum & National Jewish Health.
Papers
More filters
Journal ArticleDOI
Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
Eckard Hamelmann,Jürgen Schwarze,Katsuyuki Takeda,A. Oshiba,Gary L. Larsen,Charles G. Irvin,Erwin W. Gelfand +6 more
TL;DR: Measurement of AR to inhaled methacholine by barometric whole-body plethysmography is a valid indicator of airway hyperresponsiveness after allergic sensitization in mice, and it is shown that AR measured as Penh was associated with increased IgE production and eosinophil lung infiltration.
Journal ArticleDOI
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
TL;DR: In this review, the complete picture from epidemiology and virology to clinical impact and immunology is explored, finding that both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.
Journal ArticleDOI
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Nathan W. Bartlett,Ross P. Walton,Michael R. Edwards,Juliya Aniscenko,Gaetano Caramori,Jie Zhu,Nicholas Glanville,Katherine Choy,Patrick Jourdan,Jerome Burnet,Tobias J. Tuthill,Michael S Pedrick,Michael Hurle,Chris Plumpton,Nigel A. Sharp,James N Bussell,Dallas M. Swallow,Jürgen Schwarze,Bruno Guy,Jeffrey Almond,Peter K. Jeffery,Clare M. Lloyd,Alberto Papi,R. A. Killington,David J. Rowlands,Edward D. Blair,Neil J. Clarke,Sebastian L. Johnston +27 more
TL;DR: Three novel mouse models of rhinovirus infection have features similar to those observed in rhinvirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.
Journal ArticleDOI
Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen.
TL;DR: It is concluded that RSV infection results in airway hyperresponsiveness in the acute phase and leads to changes in immune function that can enhance the effects of airway sensitization to antigen after infection.
Journal ArticleDOI
The Human Immune Response to Respiratory Syncytial Virus Infection
TL;DR: In summary, neutrophilic inflammation is incriminated as a harmful response, whereas CD8+ T cells and IFN-γ have protective roles, which may represent important therapeutic targets to modulate the immunopathogenesis of RSV infection.