J
John Shyi Peng Yuen
Researcher at Singapore General Hospital
Publications - 39
Citations - 672
John Shyi Peng Yuen is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Prostate cancer & Prostate biopsy. The author has an hindex of 12, co-authored 38 publications receiving 540 citations. Previous affiliations of John Shyi Peng Yuen include Singapore Ministry of Health.
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Journal ArticleDOI
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
Lian Dee Ler,Sujoy Ghosh,Xiaoran Chai,Aye Aye Thike,Hong Lee Heng,Ee Yan Siew,Sucharita Dey,Liang Kai Koh,Jing Quan Lim,Weng Khong Lim,Swe Swe Myint,Jia Liang Loh,Pauline Ong,Xin Xiu Sam,Dachuan Huang,Tony Kiat Hon Lim,Puay Hoon Tan,Sanjanaa Nagarajan,Christopher Cheng,Henry Ho,Lay Guat Ng,John Shyi Peng Yuen,Po-Hung Lin,Cheng-Keng Chuang,Ying-Hsu Chang,Wen-Hui Weng,Steven G. Rozen,Patrick Tan,Caretha L. Creasy,See-Tong Pang,Michael T. McCabe,Song Ling Poon,Bin Tean Teh +32 more
TL;DR: This study demonstrates that inactivating mutations of KDM6A, which are common in urothelial bladder carcinoma, are potentially targetable by inhibiting EZH2 and small-molecule inhibitors of EZh2 were effective against KDM 6A-null bladder cancer in multiple mouse models.
Journal ArticleDOI
Effects of bladder volume on transabdominal ultrasound measurements of intravesical prostatic protrusion and volume
TL;DR: The aim of this study is to evaluate the effects of bladder volume on transabdominal ultrasound measurements of intravesical prostatic protrusion and volume.
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Optimum slicing of radical prostatectomy specimens for correlation between histopathology and medical images
Li Hong Chen,Henry Sun Sien Ho,Richie Lazaro,Choon Hua Thng,John Shyi Peng Yuen,Wan Sing Ng,Christopher Cheng +6 more
TL;DR: A standardized optimum protocol to dissect prostatectomy specimens is needed for the validation of medical imaging modalities by histologic correlation, which can enhance disease management by improving the comparability between different modalities.
Journal ArticleDOI
Comparison of the UCLA Integrated Staging System and the Leibovich Score in Survival Prediction for Patients With Nonmetastatic Clear Cell Renal Cell Carcinoma
Min-Han Tan,Min-Han Tan,Ravindran Kanesvaran,Huihua Li,Hwei Ling Tan,Puay Hoon Tan,Chin Fong Wong,Kee Seng Chia,Bin Tean Teh,Bin Tean Teh,John Shyi Peng Yuen,Tsung Wen Chong +11 more
TL;DR: Both the Leibovich model and trial criteria are superior to the UISS model and test criteria, respectively, in estimating survival outcomes in patients with nonmetastatic clear cell RCC after nephrectomy.
Journal ArticleDOI
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.
Min Thura,Abdul Qader Omer Al-aidaroos,Abhishek Gupta,Cheng Ean Chee,Soo-Chin Lee,Kam M. Hui,Jie Li,Yeoh Khay Guan,Wei Peng Yong,Jimmy Bok Yan So,Wee Joo Chng,Chin Hin Ng,Jianbiao Zhou,Lingzhi Wang,John Shyi Peng Yuen,Henry Sun Sien Ho,Sim Mei Yi,Edmund Chiong,Su Pin Choo,Joanne Ngeow,Joanne Ngeow,Matthew C.H. Ng,Clarinda Chua,Eugene Shen Ann Yeo,Iain Beehuat Tan,Joel Sng,Nicholas Yan Zhi Tan,Jean Paul Thiery,Boon Cher Goh,Qi Zeng,Qi Zeng +30 more
TL;DR: Phosphatase of regenerating liver 3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.