J
John T. O'Brien
Researcher at University of Cambridge
Publications - 873
Citations - 73158
John T. O'Brien is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dementia & Dementia with Lewy bodies. The author has an hindex of 121, co-authored 819 publications receiving 63242 citations. Previous affiliations of John T. O'Brien include Royal Melbourne Hospital & University of Western Australia.
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Ic-p-088: microglial activation and tau burden predict cognitive decline in alzheimer's disease
Maura Malpetti,Luca Passamonti,Rogier A. Kievit,P. Simon Jones,Kamen A. Tsvetanov,Timothy Rittman,Elijah Mak,W. Richard Bevan-Jones,Negin Holland,Nicolas Nicastro,Patricia Vázquez Rodríguez,Franklin I. Aigbirhio,John T. O'Brien,James B. Rowe +13 more
TL;DR: The findings support the strategy for targeting tau and neuroinflammation in disease-modifying therapy against Alzheimer’s disease and indicates the added value of PET biomarkers in predicting cognitive decline in Alzheimer's disease, over and above MRI measures of brain atrophy and demographic data.
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Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain
J. R. Highley,Ola H. Gebril,Julie E. Simpson,Stephen B. Wharton,J. Kirby,Fiona E. Matthews,John T. O'Brien,Robert Barber,Raj N. Kalaria,Carol Brayne,Claire E. Lewis,Pamela J. Shaw,Paul G. Ince +12 more
TL;DR: There was no significant difference between the lesional and control white matter, therefore, it is concluded that there is axonal preservation within these lesions that are characterized by demyelination.
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Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults
Maria-Eleni Dounavi,Audrey Low,Graciela Muniz-Terrera,Karen Ritchie,Craig W. Ritchie,Li Su,Hugh S. Markus,John T. O'Brien +7 more
TL;DR: In this article , textural features were analyzed for associations with white matter hyperintensity volume, reaction time and the Cardiovascular Risk Factors, Aging and Dementia risk score using linear regression models adjusting for age and sex.
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The promise of amplification assays for accurate early detection of α-synucleinopathies: A review
TL;DR: In this article , the diagnostic potential of amplification techniques for differentiating α-synucleinopathies from other neurodegenerative disorders such as Alzheimer's disease (AD), frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and atypical parkinsonism (Parkinsons disease dementia) from each other.
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[11c]pk11195 pet in alzheimer’s disease and progressive supranuclear palsy: the nimrod study
Patricia Vázquez Rodríguez,Luca Passamonti,Young T. Hong,William Richard Bevan-Jones,Simon Jones,Robert M. Arnold,Robin J Borchert,Ajenthan Surendranathan,Elijah Mak,Li Su,Tim D. Fryer,Franklin I. Aigbirhio,John T. O'Brien,James B. Rowe +13 more
TL;DR: Meta-analysis in MCI and Alzheimer’s confirm a faster rate of atrophy in the left hippocampus compared to the right and findings of preserved left but not right hippocampal volume due to training may therefore have implications for combating neurodegeneration.