J
John T. O'Brien
Researcher at University of Cambridge
Publications - 873
Citations - 73158
John T. O'Brien is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dementia & Dementia with Lewy bodies. The author has an hindex of 121, co-authored 819 publications receiving 63242 citations. Previous affiliations of John T. O'Brien include Royal Melbourne Hospital & University of Western Australia.
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Rodrigues fruit bats (Pteropus rodricensis, Megachiroptera: Pteropodidae) retain genetic diversity despite population declines and founder events
TL;DR: This work uses polymorphic microsatellite loci to assess genetic variability in wild, critically endangered Rodrigues fruit bats (Pteropus rodricensis, Dobson 1878) and compares this variability to that in a captive colony and document remarkable conservation of genetic variability.
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The function of the hypothalamic-pituitary-adrenal axis in Alzheimer's disease. Response to insulin hypoglycaemia.
TL;DR: The AD subjects show evidence of adrenal hyper-responsiveness and normal immediate (rate-sensitive) glucocorticoid feedback and an association between HPA axis dysfunction and organic brain pathology in AD subjects may be mediated by cell loss in the hippocampus.
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Correlation of microglial activation with white matter changes in dementia with Lewy bodies
Nicolas Nicastro,Elijah Mak,Guy B. Williams,Ajenthan Surendranathan,W Richard Bevan-Jones,Luca Passamonti,Patricia Vázquez Rodríguez,Li Su,Robert Arnold,Tim D. Fryer,Young T. Hong,Franklin I. Aigbirhio,James B. Rowe,John T. O'Brien +13 more
TL;DR: This study suggests neuroinflammation acts as an early marker of degeneration in dementias and an increased parietal microglial activation was associated with WM preservation.
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Atheromatous disease in small intracerebral vessels, microinfarcts and dementia.
TL;DR: A 97-year-old right-handed woman who was a subject in the authors' prospectively assessed cognitive function studies is described, who had a history of gastrointestinal problems which culminated in a partial gastrectomy at age 55 and had an advanced degree of dementia prior to death.