J
John T. O'Brien
Researcher at University of Cambridge
Publications - 873
Citations - 73158
John T. O'Brien is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dementia & Dementia with Lewy bodies. The author has an hindex of 121, co-authored 819 publications receiving 63242 citations. Previous affiliations of John T. O'Brien include Royal Melbourne Hospital & University of Western Australia.
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Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
TL;DR: This is the first study to show that significant progressive dopaminergic loss occurs in DLB and PDD using serial 123I-FP-CIT SPECT imaging, suggesting that dopamergic loss may play an important role in cognitive as well as motor features.
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Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease.
Michael J. Firbank,Andrew M. Blamire,Mani S. Krishnan,Andrew Teodorczuk,Philip English,Anil Gholkar,Roger Harrison,John T. O'Brien +7 more
TL;DR: Dementia disease progression as measured by global atrophy is associated with disruption of the white matter which connects posterior cingulate and lateral parietal regions, suggesting that in addition to the hypometabolism in these regions in AD and DLB, there is also disruption to thewhite matter connecting them.
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Early microglial activation and peripheral inflammation in dementia with Lewy bodies.
Ajenthan Surendranathan,Li Su,Li Su,Elijah Mak,Luca Passamonti,Young T. Hong,Robert Arnold,Patricia Vázquez Rodríguez,William Richard Bevan-Jones,Susannah A E Brain,Tim D. Fryer,Franklin I. Aigbirhio,James B. Rowe,John T. O'Brien +13 more
TL;DR: It is reported that microglial activation is elevated in mild disease, before decreasing as cognition declines, suggesting that inflammation could be targeted early in the disease.
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Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes.
Clive Ballard,Ian G. McKeith,John T. O'Brien,Rajesh N. Kalaria,Evelyn Jaros,Paul G. Ince,Robert H. Perry +6 more
TL;DR: A review of individual cases with small infarct volumes suggested that the combination of microinfarction, diffuse white matter disease and perivascular changes, or the overlap of neurodegenerative pathologies and microvascular changes were particularly important.
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Drug repositioning and repurposing for Alzheimer disease
Clive Ballard,Dag Aarsland,Dag Aarsland,Jeffrey L. Cummings,John T. O'Brien,Roger Mills,José Luis Molinuevo,Tormod Fladby,Gareth Williams,Patrick Doherty,Anne Corbett,Janet Sultana +11 more
TL;DR: This Review highlights promising compounds to prioritize for clinical trials in individuals with AD, and discusses the value of Delphi consensus methodology and evidence-based reviews to inform this prioritization process.