J
John T. O'Brien
Researcher at University of Cambridge
Publications - 873
Citations - 73158
John T. O'Brien is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dementia & Dementia with Lewy bodies. The author has an hindex of 121, co-authored 819 publications receiving 63242 citations. Previous affiliations of John T. O'Brien include Royal Melbourne Hospital & University of Western Australia.
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Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer's disease patients.
Luis R. Peraza,Ruth Cromarty,Xenia Kobeleva,Michael J. Firbank,Alison Killen,Sara Graziadio,Alan J. Thomas,John T. O'Brien,John T. O'Brien,John-Paul Taylor +9 more
TL;DR: The MST randomisation in DLB and PDD reflects decreased brain efficiency as well as impaired neural synchronisation, and the lack of network topology differences at the DF between all dementia groups and HCs may indicate a compensatory response of the brain to the neuropathology.
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Hyperintensities and Fronto-Subcortical Atrophy on MRI Are Substrates of Mild Cognitive Deficits after Stroke
Emma J. Burton,Clive Ballard,Sally Stephens,Rose Anne Kenny,Raj N. Kalaria,Robert Barber,John T. O'Brien +6 more
TL;DR: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits inFrontal atrophy is identified as a novel substrate of cognitive decline in stroke patients.
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Construction of a ‘unigene’ cDNA clone set by oligonucleotide fingerprinting allows access to 25 000 potential sugar beet genes
Ralf Herwig,Britta Schulz,Bernd Weisshaar,Steffen Hennig,Matthias Steinfath,Mario Drungowski,Dietmar Stahl,Wasco Wruck,Andreas Menze,John T. O'Brien,Hans Lehrach,Uwe Radelof +11 more
TL;DR: It is concluded that the ofp analysis pipeline is an accurate and effective way to construct large representative 'unigene' sets for any plant of interest with no requirement for prior molecular sequence data.
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Emission tomography in dementia.
Sanjeet Pakrasi,John T. O'Brien +1 more
TL;DR: Empission tomography provides a unique tool to investigate functional and neurochemical changes, both in those with established dementia and in those at risk of subsequent cognitive decline, including markers of tau, amyloid and synuclein pathology.
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Rapid eye movement sleep behavior disorder in Parkinson's disease: magnetic resonance imaging study.
Andrew H. Ford,Gordon W Duncan,Michael J. Firbank,Alison J. Yarnall,Tien K. Khoo,David J. Burn,John T. O'Brien +6 more
TL;DR: In this paper, the presence of rapid eye movement sleep behavior disorder was assessed with the Mayo Sleep Questionnaire, which was associated with subtle changes in white matter integrity and grey matter volume in patients with early Parkinson's disease.