John W. Belmont

TL;DR: The construction and testing of 20 retroviral vectors for their ability to transfer and express human ADA in vitro and in vivo via a mouse bone marrow transplantation model is described and offers the opportunity to assess methods for increasing efficiency of gene transfer, for regulation of expression of foreign genes in hematopoietic progenitors, and for long-term measurement of the stability of expression in these cells.

TL;DR: A novel role of ZIC3 in regulating cardiac gene expression is revealed and may explain, in part, the association of Zic3 mutation with cardiovascular malformations.

TL;DR: This study suggests a role for aberrant DNA methylation and cis-sequence variation in the pathogenesis of DE and highlights the diagnostic potential ofDNA methylation for teratogenic birth defects.

TL;DR: In this article, the authors present novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same, as well as vectors, host cells, antibodies and methods for producing JNK activation polypepticase polyptides.

TL;DR: The distinct cardiac lesions observed in the affected patients and the bioinformatics analyses suggest that multiple genes may be plausible drivers of the cardiac phenotype within this gene-rich critical interval of 17q25.3.