J
John W. Belmont
Researcher at Baylor College of Medicine
Publications - 284
Citations - 42331
John W. Belmont is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Population & Gene. The author has an hindex of 76, co-authored 273 publications receiving 39393 citations. Previous affiliations of John W. Belmont include Boston Children's Hospital & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Array-Based DNA Diagnostics: Let the Revolution Begin
TL;DR: High-throughput single-nucleotide polymorphism (SNP) genotyping is being widely applied in genome-wide association studies (GWASs) with recent successes in identification of common variants that confer risk for common adult diseases.
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A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping.
Chao Tian,David A. Hinds,Russell Shigeta,Sharon G. Adler,Annette Lee,Madeleine V. Pahl,Gabriel A. Silva,John W. Belmont,Robert L. Hanson,William C. Knowler,Peter K. Gregersen,Dennis G. Ballinger,Michael F. Seldin +12 more
TL;DR: It is shown, using realistic simulation parameters that are based on the analyses of MAM genotyping results, that this panel of SNP AIMs provides good power for detecting disease-associated chromosomal segments for genes with modest ethnicity risk ratios.
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A Sensitive Reporter Cell Line for HIV-1 tat Activity, HIV-1 Inhibitors, and T Cell Activation Effects
Estuardo Aguilar-Cordova,Javier Chinen,Lawrence A. Donehower,Dorothy E. Lewis,John W. Belmont +4 more
TL;DR: The production and characterization of a cell line for quantitative HIV-1 Tat function and T cell activation assays is described and the characteristics of 1G5 make it a valuable reagent for studies of HIV infection, HIV regulatory agents, and other T cell or HIV-activating factors, and for screening potential anti-HIV therapeutic agents.
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SEMA3E mutation in a patient with CHARGE syndrome
Seema R. Lalani,Arsalan M. Safiullah,Laura Molinari,Susan D. Fernbach,Donna M. Martin,John W. Belmont +5 more
TL;DR: A de novo mutation in SEMA3E in an affected patient is demonstrated upon mapping the translocation breakpoints in an unrelated individual with a de noovo balanced translocation involving chromosomes 2 and 7: karyotype 46,XY,t(2;7)(p14;q21).
Journal ArticleDOI
Recommendations for the integration of genomics into clinical practice.
Sarah Bowdin,Adel Gilbert,Emma Bedoukian,Christopher Carew,Margaret P. Adam,John W. Belmont,Barbara A. Bernhardt,Leslie G. Biesecker,Hans T. Bjornsson,Miriam G. Blitzer,Lisa C.A. D'Alessandro,Matthew A. Deardorff,Laurie A. Demmer,Alison M. Elliott,Gerald L. Feldman,Ian A. Glass,Gail E. Herman,Lucia A. Hindorff,Fuki M. Hisama,Louanne Hudgins,A. Micheil Innes,Laird G. Jackson,Gail P. Jarvik,Raymond H. Kim,Bruce R. Korf,David H. Ledbetter,Mindy H. Li,Eriskay Liston,Christian R. Marshall,Livija Medne,Livija Medne,M. Stephen Meyn,M. Stephen Meyn,Nasim Monfared,Cynthia C. Morton,John J. Mulvihill,Sharon E. Plon,Heidi L. Rehm,Amy E. Roberts,Cheryl Shuman,Cheryl Shuman,Nancy B. Spinner,D James Stavropoulos,Kathleen Valverde,Darrel Waggoner,Alisha Wilkens,Ronald D. Cohn,Ronald D. Cohn,Ian D. Krantz +48 more
TL;DR: Recommendations are provided that will guide the integration of genomics into clinical practice and address the evolving role of the clinical geneticist in the rapidly changing climate of genomic medicine.