J
Johnathan Canton
Researcher at Francis Crick Institute
Publications - 30
Citations - 2066
Johnathan Canton is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Phagocytosis & Antigen. The author has an hindex of 18, co-authored 26 publications receiving 1555 citations. Previous affiliations of Johnathan Canton include University of Florida.
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Scavenger receptors in homeostasis and immunity
TL;DR: This Review highlights recent insights into the structural features that determine the function of scavenger receptors and the emerging role that these receptors have in immune responses, notably in macrophage polarization and in the pathogenesis of diseases such as atherosclerosis and Alzheimer's disease.
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The life cycle of phagosomes: formation, maturation, and resolution
TL;DR: The molecular events underlying these stages are being unraveled and the current state of knowledge is briefly summarized in this article.
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Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages.
TL;DR: Phagosomal pH is regulated in diametrically opposed ways in M1 and M2 macrophages, whereas M2 phagosomes acidify rapidly and monotonically.
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Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages
Johnathan Canton,Daniel Schlam,Christian Breuer,Michael Gütschow,Michael Glogauer,Sergio Grinstein +5 more
TL;DR: It is reported that constitutive macrop inocytosis is stringently calcium dependent, while stimulus-induced macropinocytotic is not, and it is shown that CaSR-induced constitutiveMacropincytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors.
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mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
Amra Saric,Victoria E. B. Hipolito,Jason G. Kay,Johnathan Canton,Costin N. Antonescu,Roberto J. Botelho +5 more
TL;DR: Evidence shows that mTOR may control lysosome tubulation by modulating microtubule motor activity through Arl8b.