J
Jonathan M. Fenkel
Researcher at Thomas Jefferson University
Publications - 47
Citations - 1446
Jonathan M. Fenkel is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Hepatitis C & Portal hypertension. The author has an hindex of 10, co-authored 43 publications receiving 1291 citations. Previous affiliations of Jonathan M. Fenkel include Harvard University & Thomas Jefferson University Hospital.
Papers
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Journal ArticleDOI
Sofosbuvir and velpatasvir for HCV in patients with decompensated cirrhosis
Michael P. Curry,Jacqueline G. O'Leary,Natalie Bzowej,Andrew J. Muir,Kevin M. Korenblat,Jonathan M. Fenkel,K. R. Reddy,E. Lawitz,Steven L. Flamm,T. Schiano,L. Teperman,Robert J. Fontana,E. Schiff,Michael W. Fried,Brian P. Doehle,D. An,J. McNally,A. O. Osinusi,Diana M. Brainard,John G. McHutchison,Robert S. Brown,Michael Charlton +21 more
TL;DR: Treatment with sofosbuvir-velpatasvir with or without ribavirin for 12 weeks and with so-called "superdrugs" for 24 weeks resulted in high rates of sustained virologic response in patients with HCV infection and decompensated cirrhosis.
Journal ArticleDOI
Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection After Liver Transplantation: An Open-Label Study
Michael P. Curry,Xavier Forns,Raymond T. Chung,Norah A. Terrault,Robert S. Brown,Jonathan M. Fenkel,Fredric D. Gordon,Jacqueline G. O'Leary,Alexander Kuo,Thomas D. Schiano,Gregory T. Everson,Eugene R. Schiff,Alex S. Befeler,Edward Gane,Sammy Saab,John G. McHutchison,G. Mani Subramanian,William T. Symonds,Jill Denning,Lindsay McNair,Sarah Arterburn,Evguenia S. Svarovskaia,Dilip Moonka,Nezam H. Afdhal +23 more
TL;DR: Administration of sofosbuvir and ribavirin before liver transplantation can prevent post-transplant HCV recurrence, related inversely to the number of consecutive days of undetectable HCV RNA before transplantation.
Journal ArticleDOI
Effectiveness of Simeprevir Plus Sofosbuvir, with or Without Ribavirin, in Real-World Patients with HCV Genotype 1 Infection
Mark S. Sulkowski,Hugo E. Vargas,Adrian M. Di Bisceglie,Alexander Kuo,K. Rajender Reddy,Joseph K. Lim,Giuseppe Morelli,Jama M. Darling,Jordan J. Feld,Robert S. Brown,Lynn M. Frazier,Thomas G. Stewart,Michael W. Fried,David R. Nelson,Ira M. Jacobson,Nezam H. Afdhal,Imtiaz Alam,Ziv Ben-Ari,J. Bredfeldt,R.S. Brown,R.T. Chung,J. Darling,W. Harlan,A. M. Di Bisceglie,Rolland C. Dickson,H.A. Elbeshbeshy,Gregory T. Everson,Jordan J. Feld,Jonathan M. Fenkel,M.W. Fried,Joseph S. Galati,S.C. Gordon,Mohamed Hassan,T.N. Hawkins,Federico Hinestrosa,I.M. Jacobson,C.A. Kerr,A. Kuo,P. Kwo,Josh Levitsky,J. Lim,A.S. Lok,Mark E. Mailliard,Michael P. Manns,G. Morelli,Andrew J. Muir,D. Nelson,Jacqueline G. O'Leary,Brian L. Pearlman,P. Pockros,Ananthakrishnan Ramani,Nancy Reau,K.R. Reddy,Eugene R. Schiff,Kenneth E. Sherman,Mitchell L. Shiffman,Coleman Smith,J.R. Spivey,Richard K. Sterling,M.S. Sulkowski,Gyongyi Szabo,Norah A. Terrault,C. Trautwein,H.E. Vargas,K. Watts,A. Williams,Stefan Zeuzem +66 more
TL;DR: In a large prospective observational cohort study, a 12-week regimen of simeprevir plus sofosbuvir was associated with high rates of sustained virologic response (SVR) and infrequent treatment discontinuation.
Journal ArticleDOI
Diagnosing Portal Hypertension with Noninvasive Subharmonic Pressure Estimates from a US Contrast Agent.
Ipshita Gupta,John R. Eisenbrey,Priscilla Machado,Maria Stanczak,Corinne E. Wessner,Colette M. Shaw,Sriharsha Gummadi,Jonathan M. Fenkel,Alison Tan,Cynthia Miller,Julia Parent,Susan M. Schultz,Michael C. Soulen,Chandra M. Sehgal,Kirk D. Wallace,Flemming Forsberg +15 more
TL;DR: Comparing quantitative SHAPE to HVPG measurements to diagnose portal hypertension in participants undergoing a transjugular liver biopsy found that subharmonic-aided pressure estimation is an accurate noninvasive technique for detecting clinically significant portal hypertension.
Journal Article
Herbal and dietary supplement-induced liver injury
TL;DR: The case reported by Inoue and colleagues lacks a formal causality assessment, but causality is more straightforward in this case than in most cases of HDS-induced liver injury, as this patient was taking no other supplements or medications preceding the acute liver injury.