J
Jonathan P. Dyke
Researcher at Cornell University
Publications - 146
Citations - 5769
Jonathan P. Dyke is an academic researcher from Cornell University. The author has contributed to research in topics: Magnetic resonance imaging & Medicine. The author has an hindex of 36, co-authored 126 publications receiving 4821 citations. Previous affiliations of Jonathan P. Dyke include Memorial Sloan Kettering Cancer Center & University of Tennessee.
Papers
More filters
Journal ArticleDOI
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.
Stefan Worgall,Dolan Sondhi,Neil R. Hackett,Barry E. Kosofsky,Minal V. Kekatpure,Nurunisa Neyzi,Jonathan P. Dyke,Douglas Ballon,Linda Heier,Bruce M. Greenwald,Paul J. Christos,Madhu Mazumdar,Mark M. Souweidane,Michael G. Kaplitt,Ronald G. Crystal +14 more
TL;DR: Assessment of the primary outcome variable suggests a slowing of progression of LINCL in the treated children, and it is proposed that additional studies to assess the safety and efficacy of AAV-mediated gene therapy for LINCL are warranted.
Journal ArticleDOI
Study of Intraventricular Cerliponase Alfa for CLN2 Disease.
Angela Schulz,Temitayo Ajayi,Nicola Specchio,Emily de los Reyes,Paul Gissen,Douglas Ballon,Jonathan P. Dyke,H. Cahan,P. Slasor,D. Jacoby,Alfried Kohlschütter +10 more
TL;DR: Intraventricular infusion of cerliponase alfa in patients with CLN2 disease resulted in less decline in motor and language function than that in historical controls.
Journal ArticleDOI
Possible axonal regrowth in late recovery from the minimally conscious state.
Henning U. Voss,Aziz M. Uluç,Jonathan P. Dyke,Richard Watts,Erik J. Kobylarz,Bruce D. McCandliss,Linda Heier,Bradley J. Beattie,Klaus A. Hamacher,Shankar Vallabhajosula,Stanley J. Goldsmith,Douglas Ballon,Joseph T. Giacino,Nicholas D. Schiff +13 more
TL;DR: It is proposed that axonal regrowth may underlie these findings and provide a biological mechanism for late recovery and is discussed in the context of recent experimental studies that support this inference.
Journal ArticleDOI
The Medial Prefrontal Cortex and the Emergence of Self-Conscious Emotion in Adolescence
Leah H. Somerville,Rebecca M. Jones,Erika J. Ruberry,Jonathan P. Dyke,Gary H. Glover,B. J. Casey +5 more
TL;DR: Findings demonstrate that adolescents’ self-consciousness is related to age-dependent sensitivity of brain systems critical to socioaffective processes, and unique interactions between the MPFC and striatum may provide a mechanism by which social-evaluation contexts influence adolescent behavior.
Journal ArticleDOI
Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury
Jonathan C. Bardin,Joseph J. Fins,Douglas I. Katz,Jennifer Hersh,Linda Heier,Karsten Tabelow,Jonathan P. Dyke,Douglas Ballon,Nicholas D. Schiff,Henning U. Voss +9 more
TL;DR: Observations reveal significant challenges in developing validated functional magnetic resonance imaging-based methods for clinical use and raise interesting questions about underlying brain function assayed using these methods in brain-injured subjects.