Bruce M. Greenwald

TL;DR: The 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock continues to emphasize early use of age-specific therapies to attain time-sensitive goals, and a major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained.

TL;DR: A major new recommendation in the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock” is consideration of institution—specific use of a recognition bundle containing a trigger tool for rapid identification of patients with septic shock.

TL;DR: Assessment of the primary outcome variable suggests a slowing of progression of LINCL in the treated children, and it is proposed that additional studies to assess the safety and efficacy of AAV-mediated gene therapy for LINCL are warranted.

TL;DR: The Cornell Assessment of Pediatric Delirium is a valid, rapid, observational nursing screen that is urgently needed for the detection of delirium in PICU settings.

TL;DR: The frequency of delirium in critically ill children, its duration, associated risk factors, and effect on in-hospital outcomes, including mortality are described, with a strong and independent predictor of mortality.