M
Mark M. Souweidane
Researcher at Cornell University
Publications - 275
Citations - 7762
Mark M. Souweidane is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 44, co-authored 232 publications receiving 6520 citations. Previous affiliations of Mark M. Souweidane include University of Toronto & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Pawel Buczkowicz,Christine M. Hoeman,Patricia Rakopoulos,Sanja Pajovic,Louis Letourneau,Misko Dzamba,Andrew Morrison,Peter W. Lewis,Eric Bouffet,Ute Bartels,Jennifer Zuccaro,Sameer Agnihotri,Scott Ryall,Mark Barszczyk,Yevgen Chornenkyy,Mathieu Bourgey,Guillaume Bourque,Alexandre Montpetit,Francisco Cordero,Pedro Castelo-Branco,Joshua Mangerel,Uri Tabori,King Ching Ho,Annie Huang,Kathryn R. Taylor,Alan Mackay,Anne Bendel,Javad Nazarian,Jason Fangusaro,Matthias A. Karajannis,David Zagzag,Nicholas K. Foreman,Andrew M. Donson,Julia V Hegert,Amy Smith,Jennifer A. Chan,Lucy Lafay-Cousin,Sandra E. Dunn,Juliette Hukin,Chris Dunham,Katrin Scheinemann,Jean Michaud,Shayna Zelcer,David A. Ramsay,Jason E. Cain,Cameron Brennan,Mark M. Souweidane,Chris Jones,C. David Allis,Michael Brudno,Michael Brudno,Oren J. Becher,Cynthia Hawkins +52 more
TL;DR: This work integrated whole-genome sequencing with methylation, expression and copy number profiling, discovering that DIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPG.
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Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.
Stefan Worgall,Dolan Sondhi,Neil R. Hackett,Barry E. Kosofsky,Minal V. Kekatpure,Nurunisa Neyzi,Jonathan P. Dyke,Douglas Ballon,Linda Heier,Bruce M. Greenwald,Paul J. Christos,Madhu Mazumdar,Mark M. Souweidane,Michael G. Kaplitt,Ronald G. Crystal +14 more
TL;DR: Assessment of the primary outcome variable suggests a slowing of progression of LINCL in the treated children, and it is proposed that additional studies to assess the safety and efficacy of AAV-mediated gene therapy for LINCL are warranted.
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Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid
Alexandra Miller,Ronak Shah,Elena Pentsova,Maryam Pourmaleki,Samuel Briggs,Natalie DiStefano,Youyun Zheng,Anna Skakodub,Smrutiben A. Mehta,Carl Campos,Wan-Ying Hsieh,S. Duygu Selcuklu,Lilan Ling,Fanli Meng,Xiaohong Jing,Aliaksandra Samoila,Tejus Bale,Dana W.Y. Tsui,Christian Grommes,Agnes Viale,Mark M. Souweidane,Mark M. Souweidane,Viviane Tabar,Cameron Brennan,Anne S. Reiner,Marc K. Rosenblum,Katherine S. Panageas,Lisa M. DeAngelis,Robert J. Young,Michael F. Berger,Ingo K. Mellinghoff,Ingo K. Mellinghoff +31 more
TL;DR: It is shown that tumour-derived DNA was detected in CSF from 42 out of 85 patients (49.4%) and was associated with disease burden and adverse outcome and the ability to monitor the evolution of the glioma genome through a minimally invasive technique could advance the clinical development and use of genotype-directed therapies for gliomas.
Journal ArticleDOI
An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions.
Joy Hirsch,Maximilian I. Ruge,Maximilian I. Ruge,Karl H. S. Kim,Denise D. Correa,Denise D. Correa,Jonathan D. Victor,Norman R. Relkin,Douglas Labar,George Krol,Mark H. Bilsky,Mark M. Souweidane,Lisa M. DeAngelis,Philip H. Gutin +13 more
TL;DR: This integrated fMRI task battery offers standardized and noninvasive preoperative maps of multiple critical functions to facilitate assessment of surgical risk, planning of surgical routes, and direction of conventional, intraoperative electrophysiological procedures.
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Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma.
Kim Kramer,Brian H. Kushner,Shakeel Modak,Neeta Pandit-Taskar,Peter Smith-Jones,Pat Zanzonico,John L. Humm,Hong Xu,Suzanne L. Wolden,Mark M. Souweidane,Steven M. Larson,Nai-Kong V. Cheung +11 more
TL;DR: The cRIT-salvage regimen for CNS metastases was well tolerated by young patients, despite their prior history of intensive cytotoxic therapies, and has the potential to increase survival with better than expected quality of life.