Jong Heun Lee

TL;DR: Analysis of the expression of HDAC2 in 71 gastric adenocarcinomas by immunohistochemistry suggests thatHDAC2 may play an important role in the aggressiveness of gastric cancer.

TL;DR: The analysis of death domains of Fas and tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 and -2 genes suggests that TRAIL-R1 and R2 genes are relevant to the frequent loss of chromosome 8p21-22 in breast cancer and that the inactivating mutations of TRAil- R1 and -R2 genes play a role in the metastasis of breast cancer.

TL;DR: The presence of caspase-8 mutation in colon carcinomas suggests that casp enzyme-8 gene mutation might lead to the loss of its apoptotic function and contribute to the pathogenesis of colorectal carcinomas, especially at the late stage of colorean carcinogenesis.

TL;DR: The data indicate that somatic mutation of TRAIL-R2 may play a role in the pathogenesis of some NSCLCs and that the TRAIL -R2 gene is one of the genes relevant to the frequent loss of chromosome 8p21-22 in NSCLC.

TL;DR: The data suggest that somatic mutations of TRAil-R1 and TRAIL-R2 genes may play a role in the pathogenesis of some NHLs and that these genes might be the relevant genes to the frequent loss of chromosome 8p21-22 in human NHL.