J
Jordan J Licata
Researcher at National Institutes of Health
Publications - 2
Citations - 205
Jordan J Licata is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Bone mineral. The author has an hindex of 2, co-authored 2 publications receiving 171 citations.
Papers
More filters
Journal ArticleDOI
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Evi M. Mercken,Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Alejandro Martin-Montalvo,Robin K. Minor,Maria Almeida,Ana P. Gomes,Morten Scheibye-Knudsen,Hector H. Palacios,Jordan J Licata,Yongqing Zhang,Kevin G. Becker,Husam Khraiwesh,José A. González-Reyes,José M. Villalba,Joseph A. Baur,Peter J. Elliott,Christoph H. Westphal,George P. Vlasuk,James L. Ellis,David A. Sinclair,Michel Bernier,Rafael de Cabo +23 more
TL;DR: It is shown that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet, accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation.
Journal ArticleDOI
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
Dushani L. Palliyaguru,Robin K. Minor,Sarah J. Mitchell,Hector H. Palacios,Jordan J Licata,Theresa M. Ward,Gelareh Abulwerdi,Peter J. Elliott,Christoph H. Westphal,James L. Ellis,David A. Sinclair,Nathan L. Price,Michel Bernier,Rafael de Cabo +13 more
TL;DR: The data suggest that co-treatment of SRT1720 with MET is detrimental to survival at the doses used and, therefore, risk-benefits of combining lifespan-extending drugs especially in older populations needs to be systematically evaluated.