S
Sarah J. Mitchell
Researcher at Harvard University
Publications - 87
Citations - 5832
Sarah J. Mitchell is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 28, co-authored 70 publications receiving 4264 citations. Previous affiliations of Sarah J. Mitchell include ETH Zurich & National Institutes of Health.
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Journal ArticleDOI
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo,Evi M. Mercken,Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Hector H. Palacios,Patricia L. Mote,Morten Scheibye-Knudsen,Ana P. Gomes,Theresa M. Ward,Robin K. Minor,Marie-José Blouin,Matthias Schwab,Michael Pollak,Yongqing Zhang,Yinbing Yu,Kevin G. Becker,Vilhelm A. Bohr,Donald K. Ingram,David A. Sinclair,Norman S. Wolf,Stephen R. Spindler,Michel Bernier,Rafael de Cabo +23 more
TL;DR: It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
Journal ArticleDOI
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Sarah J. Mitchell,Julio Madrigal-Matute,Morten Scheibye-Knudsen,Morten Scheibye-Knudsen,Evandro Fei Fang,Miguel A. Aon,José A. González-Reyes,Sonia Cortassa,Susmita Kaushik,Marta Gonzalez-Freire,Bindi Patel,Devin Wahl,Ahmed Ali,Miguel Calvo-Rubio,M. I. Burón,Vincent Guiterrez,Theresa M. Ward,Hector H. Palacios,Huan Cai,David W. Frederick,Christopher Hine,Filomena Broeskamp,Lukas Habering,John Dawson,John Dawson,T. Mark Beasley,T. Mark Beasley,Junxiang Wan,Yuji Ikeno,Gene B. Hubbard,Kevin G. Becker,Yongqing Zhang,Vilhelm A. Bohr,Dan L. Longo,Plácido Navas,Luigi Ferrucci,David A. Sinclair,Pinchas Cohen,Josephine M. Egan,James R. Mitchell,Joseph A. Baur,David B. Allison,David B. Allison,R. Michael Anson,José M. Villalba,Frank Madeo,Ana Maria Cuervo,Kevin J. Pearson,Kevin J. Pearson,Donald K. Ingram,Michel Bernier,Rafael de Cabo +51 more
TL;DR: The authors' data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.
Journal ArticleDOI
The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Alejandro Martin-Montalvo,Evi M. Mercken,Hector H. Palacios,Theresa M. Ward,Gelareh Abulwerdi,Robin K. Minor,George P. Vlasuk,James L. Ellis,David A. Sinclair,John A. Dawson,David B. Allison,Yongqing Zhang,Kevin G. Becker,Michel Bernier,Rafael de Cabo +17 more
TL;DR: This study found extension in lifespan, delayed onset of age-related metabolic diseases, and improved general health in mice fed a standard diet after SRT1720 supplementation and further supports the beneficial effects of SRT 1720 on health across the lifespan in mice.
Journal ArticleDOI
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.
Paula Mera,Kathrin Laue,Mathieu Ferron,Cyril Confavreux,Jianwen Wei,Marta Galán-Díez,Alain Lacampagne,Sarah J. Mitchell,Julie A. Mattison,Yun Chen,Justine Bacchetta,Pawel Szulc,Richard N. Kitsis,Rafael de Cabo,Richard A. Friedman,Christopher Torsitano,Timothy E. McGraw,Michelle Puchowicz,Irwin J. Kurland,Gerard Karsenty +19 more
TL;DR: This study uncovers a bone-to-muscle feedforward endocrine axis that favors adaptation to exercise and can reverse the age-induced decline in exercise capacity.
Journal ArticleDOI
A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
Morten Scheibye-Knudsen,Sarah J. Mitchell,Sarah J. Mitchell,Evandro Fei Fang,Teruaki Iyama,Theresa H. Ward,James Q. Wang,Christopher A. Dunn,Nagendra Singh,Sebastian Veith,Mahdi Hasan-Olive,Aswin Mangerich,Mark A. Wilson,Mark P. Mattson,Linda H. Bergersen,Linda H. Bergersen,Victoria C. Cogger,Alessandra Warren,David G. Le Couteur,Ruin Moaddel,David M. Wilson,Deborah L. Croteau,Rafael de Cabo,Vilhelm A. Bohr,Vilhelm A. Bohr +24 more
TL;DR: This study connects two emerging longevity metabolites, β-hydroxybutyrate and NAD(+), through the deacetylase SIRT1 and suggests possible interventions for CS.