Husam Khraiwesh

TL;DR: It is shown that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet, accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation.

TL;DR: The oxidative perturbation in APS patient leukocytes relies on alterations in mitochondrial dynamics and metabolism that may be prevented, reverted, or both by treatment with coenzyme Q(10) (CoQ(10).

TL;DR: The overall data suggest that fluvastatin improves the impairment of a redox-sensitive pathway involved in processes that collectively orchestrate the pathophysiology of atherothrombosis in SLE.

TL;DR: Changing membrane lipid composition by different fat sources did modulate the effects of CR on hepatocyte mitochondria, and many of these changes could be attributed to CR regardless of dietary fat.

TL;DR: Results show that CR induced changes in hepatocyte and mitochondrial size, in the volume fraction occupied by mitochondria, and in the number of mitochondria per hepatocyte, supporting the idea that dietary fat plays a relevant role in the modulation of CR effects in aged mice.