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Alejandro Martin-Montalvo
Researcher at Pablo de Olavide University
Publications - 58
Citations - 7120
Alejandro Martin-Montalvo is an academic researcher from Pablo de Olavide University. The author has contributed to research in topics: Mitochondrion & Insulin resistance. The author has an hindex of 28, co-authored 54 publications receiving 5724 citations. Previous affiliations of Alejandro Martin-Montalvo include National Institutes of Health & Spanish National Research Council.
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Journal ArticleDOI
SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
Nathan L. Price,Ana P. Gomes,Alvin J. Y. Ling,Filipe V. Duarte,Alejandro Martin-Montalvo,Brian J. North,Beamon Agarwal,Lan Ye,Giorgio Ramadori,João S. Teodoro,Basil P. Hubbard,Ana T. Varela,James G. Davis,Behzad Varamini,Angela Hafner,Ruin Moaddel,Anabela P. Rolo,Roberto Coppari,Roberto Coppari,Carlos M. Palmeira,Rafael de Cabo,Joseph A. Baur,David A. Sinclair,David A. Sinclair +23 more
TL;DR: Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits, whereas a mouse overexpressing Sirt1 mimicked these effects.
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Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo,Evi M. Mercken,Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Hector H. Palacios,Patricia L. Mote,Morten Scheibye-Knudsen,Ana P. Gomes,Theresa M. Ward,Robin K. Minor,Marie-José Blouin,Matthias Schwab,Michael Pollak,Yongqing Zhang,Yinbing Yu,Kevin G. Becker,Vilhelm A. Bohr,Donald K. Ingram,David A. Sinclair,Norman S. Wolf,Stephen R. Spindler,Michel Bernier,Rafael de Cabo +23 more
TL;DR: It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
Jaime Guevara-Aguirre,Priya Balasubramanian,Marco Guevara-Aguirre,Min Wei,Federica Madia,Chia-Wei Cheng,David Hwang,Alejandro Martin-Montalvo,Alejandro Martin-Montalvo,Jannette Saavedra,Sue A. Ingles,Rafael de Cabo,Pinchas Cohen,Valter D. Longo +13 more
TL;DR: Although it is difficult to prove that alterations in IGF-1 amounts are responsible for the cancer- and diabetes-free lives of these Ecuadorian people, genetic work from several model organisms suggests that this is so, and mutations in growth signaling pathways extend life span and reduce abnormal cellular proliferation in worms.
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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Changhan Lee,Lizzia Raffaghello,Sebastian Brandhorst,Sebastian Brandhorst,Fernando M. Safdie,Giovanna Bianchi,Alejandro Martin-Montalvo,Vito Pistoia,Min Wei,Saewon Hwang,Annalisa Merlino,Laura Emionite,Rafael de Cabo,Valter D. Longo +13 more
TL;DR: It is suggested that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.
Journal ArticleDOI
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
Changhan Lee,Jennifer Zeng,Brian G. Drew,Tamer Sallam,Alejandro Martin-Montalvo,Junxiang Wan,Su-Jeong Kim,Hemal H. Mehta,Andrea L. Hevener,Rafael de Cabo,Pinchas Cohen +10 more
TL;DR: Treatment with MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity, and suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.