J
Jordan R. Barrett
Researcher at University of Oxford
Publications - 25
Citations - 2078
Jordan R. Barrett is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Vaccination. The author has an hindex of 9, co-authored 17 publications receiving 838 citations.
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Journal ArticleDOI
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
Merryn Voysey,S A Costa Clemens,Shabir A. Madhi,Lily Yin Weckx,P M Folegatti,Parvinder K. Aley,Brian Angus,Vicky L. Baillie,Vicky L. Baillie,Shaun Barnabas,Q E Bhorat,S Bibi,Carmen Briner,P Cicconi,Elizabeth A. Clutterbuck,Andrea M. Collins,Clare L. Cutland,Clare L. Cutland,Thomas C. Darton,Keertan Dheda,Christina Dold,Duncan Cja.,Emary Krw.,Katie J. Ewer,Amy Flaxman,Lee Fairlie,Saul N. Faust,Shuo Feng,Daniela M. Ferreira,Adam Finn,Eva P. Galiza,Anna Goodman,Catherine M. Green,Christopher A Green,Melanie Greenland,Christopher Hill,Christopher Hill,Helen Hill,Ian Hirsch,Alane Izu,Alane Izu,D Jenkin,Joe Ccd.,Simon Kerridge,Anthonet Koen,Anthonet Koen,Gaurav Kwatra,Gaurav Kwatra,Rajeka Lazarus,Vincenzo Libri,Patrick J. Lillie,N G Marchevsky,R P Marshall,Mendes Ava.,Eveline Pipolo Milan,Angela M. Minassian,Alastair McGregor,Yama F Mujadidi,Amit J Nana,S D Padayachee,Daniel J. Phillips,A Pittella,Emma Plested,Katrina M Pollock,M N Ramasamy,Adam J. Ritchie,Hannah Robinson,Alexandre Vargas Schwarzbold,Andrew Smith,R Song,Matthew D. Snape,Eduardo Sprinz,Rebecca K. Sutherland,E. Thomson,M E Török,Mark Toshner,Turner Dpj.,Johan Vekemans,Tonya Villafana,Thomas E. White,C J Williams,Alexander D. Douglas,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard,M Aban,Abeyskera Kwm.,J Aboagye,M Adam,Kirsty Adams,J P Adamson,G Adewatan,Syed Adlou,Katie A. Ahmed,Y Akhalwaya,S Akhalwaya,A Alcock,A Ali,Elizabeth R. Allen,Lauren Allen,F B Alvernaz,F S Amorim,C S Andrade,F Andritsou,Rachel Anslow,E H Arbe-Barnes,Mark P. Ariaans,B Arns,L Arruda,L Assad,Azi Pda.,Azi Lda.,G Babbage,C Bailey,K F Baker,Megan Baker,Natalie Baker,Philip Baker,I Baleanu,D Bandeira,A Bara,Barbosa Mas.,D Barker,Gavin Barlow,Eleanor Barnes,A S Barr,Jordan R. Barrett,Jeffrey C. Barrett,K Barrett,L Bates,A Batten,Kirsten Beadon,E Beales,R Beckley,Sandra Belij-Rammerstorfer,Jennifer L Bell,D Bellamy,S Belton,Adam Berg,L Bermejo,Eleanor Berrie,Louise Berry,D Berzenyi,Amy Beveridge,Kevin R. Bewley,I Bharaj,Sutika Bhikha,As’ad E. Bhorat,Z E Bhorat,E M Bijker,Sarah Birch,G Birch,K Birchall,A Bird,O Bird,Karen Bisnauthsing,M Bittaye,L Blackwell,R Blacow,H Bletchly,C L Blundell,Blundell,P Bodalia,E Bolam,E Boland,D Bormans,N Borthwick,F Bowring,Amy Boyd,P Bradley,T Brenner,Alice Bridges-Webb,Phillip Brown,Colin S Brown,C Brown-O’Sullivan,S Bruce,Emily Brunt,W Budd,Y A Bulbulia,Matthew J. Bull,J Burbage,A Burn,Karen R. Buttigieg,N Byard,I Cabrera Puig,Anna M. Calvert,S Camara,M Cao,Federica Cappuccini,R Cardona,Cardoso,M Carr,Miles W. Carroll,Andrew Carson-Stevens,Carvalho Ydm.,H R Casey,P Cashen,Castro Try.,L C Castro,Katrina Cathie,A Cavey,J Cerbino-Neto,Cezar Lff.,J Chadwick,C Chanice,Daniel Chapman,Sue Charlton,K S Cheliotis,Irina Chelysheva,O Chester,E Chiplin,S Chita,Cho J-S.,Lucía Cifuentes,E Clark,M Clark,R Colin-Jones,Collins Slk.,Hayley Colton,Christopher P. Conlon,S Connarty,Naomi Coombes,Cyrus Cooper,R Cooper,L Cornelissen,T Corrah,Catherine Cosgrove,F B Costa,T Cox,Crocker Wem.,S Crosbie,D Cullen,Cunha Drmf.,C J Cunningham,F C Cuthbertson,D M da Costa,Da Guarda Snf.,L P da Silva,A C da Silva Moraes,B E Damratoski,Z Danos,Dantas Mtdc.,M Datoo,C Datta,M Davids,Shân Davies,Kelly Davies,Heather Davies,Steve Davies,Jane C. Davies,E J Davis,J Davis,de Carvalho Jam.,J. P. de Jager,S de Jesus Jnr,L M De Oliveira Kalid,D Dearlove,Tesfaye Demissie,Amisha Desai,S Di Marco,C Di Maso,Tanya Dinesh,C Docksey,Tao Dong,Francesca R. Donnellan,T G Dos Santos,E P Dos Santos,N Douglas,C Downing,J Drake,R Drake-Brockman,Ruth E Drury,J. M. E. Du Plessis,Susanna Dunachie,A Duncan,Easom Njw.,Michelle Edwards,Nick J. Edwards,F Edwards,O M El Muhanna,Sean C. Elias,B Ellison-Handley,M J Elmore,M R English,Aliasgar Esmail,Y M Essack,M Farooq,Sofiya Fedosyuk,Sally Felle,S Ferguson,C Ferreira Da Silva,S Field,R Fisher,J Fletcher,H Fofie,H Fok,K J Ford,R Fothergill,J Fowler,Fraiman Pha.,E Francis,M M Franco,John Frater,Freire Msm.,S H Fry,S Fudge,R Furlan Filho,J Furze,Michelle Fuskova,P Galian-Rubio,H Garlant,M Gavrila,K A Gibbons,Ciaran Gilbride,Harmeet Gill,Kerry Godwin,Karishma Gokani,Gonçalves Mlf.,Gonzalez Igs.,J Goodall,J Goodwin,A Goondiwala,K Gordon-Quayle,G Gorini,A Goyanna,J Grab,L Gracie,J Green,N Greenwood,J Greffrath,M M Groenewald,A Gunawardene,Gaurav Gupta,M Hackett,Bassam Hallis,M Hamaluba,E Hamilton,J Hamlyn,D Hammersley,A T Hanrath,B Hanumunthadu,S A Harris,C Harris,T D Harrison,D Harrison,T A Harris-Wright,T C Hart,B Hartnell,J Haughney,S Hawkins,Hayano Lym.,I Head,Paul T. Heath,J A Henry,M Hermosin Herrera,David Hettle,C Higa,Jennifer Hill,G Hodges,Susanne H Hodgson,E Horne,M M Hou,C F Houlihan,E Howe,N Howell,J Humphreys,Holly E. Humphries,K Hurley,C Huson,Catherine Hyams,A Hyder-Wright,S Ikram,Alka Ishwarbhai,P Iveson,V Iyer,F Jackson,S Jackson,S Jaumdally,H Jeffers,Natasha Jesudason,C. Jones,K Jones,E Y Jones,M R Jorge,A Joshi,Júnior Eams.,Reshma Kailath,F Kana,A Kar,K Karampatsas,Mwila Kasanyinga,L Kay,J Keen,J Kellett Wright,Elizabeth J. Kelly,Deirdre Kelly,D M Kelly,Sarah Kelly,D Kerr,L Khan,B Khozoee,A Khurana,Stephen P. Kidd,A Killen,J Kinch,P Kinch,King Ldw.,T B King,L Kingham,Paul Klenerman,D M Kluczna,F Knapper,Julian C. Knight,D Knott,S Koleva,P M Lages,M Lang,G Lang,C W Larkworthy,Larwood Jpj.,R Law,Alison M. Lawrie,E M Lazarus,Amanda J. Leach,E A Lees,A Lelliott,Lemm N-M.,Lessa Aer.,S Leung,Y Li,A M Lias,K Liatsikos,A Linder,S Lipworth,S Liu,X Liu,A Lloyd,S Lloyd,L Loew,R Lopez Ramon,L B Lora,K G Luz,J C MacDonald,G MacGregor,M Madhavan,David O. Mainwaring,E Makambwa,R Makinson,M Malahleha,R Malamatsho,G Mallett,N Manning,K Mansatta,T Maoko,S Marinou,E Marlow,G N Marques,P Marriott,J L Marshall,Masebole Masenya,Mduduzi Masilela,S K Masters,M Mathew,H Matlebjane,K Matshidiso,O Mazur,A Mazzella,H McCaughan,J McEwan,J McGlashan,L McInroy,N McRobert,S McSwiggan,C Megson,S Mehdipour,W Meijs,Mendonça Rnõ.,Alexander J. Mentzer,Mesquita Acf.,P Miralhes,N Mirtorabi,Celia Mitton,S Mnyakeni,F Moghaddas,K Molapo,M Moloi,Maria Moore,M Moran,E Morey,R Morgans,Susan J. Morris,S J Morris,Hazel Morrison,F Morselli,G Morshead,R Morter,L Mottay,A Moultrie,N Moyo,M Mpelembue,S Msomi,Y Mugodi,E Mukhopadhyay,J Muller,Alasdair Munro,Sinéad M. Murphy,P Mweu,C Myerscough,G Naik,Kush Naker,Eleni Nastouli,B Ndlovu,E Nikolaou,C Njenga,H C Noal,Amy R. Noe,G Novaes,Fay L. Nugent,Nunes Gla.,Katherine L. O'Brien,Daniel H. O'Connor,Oelofse S,Blanche Oguti,V Olchawski,Neil J. Oldfield,M G Oliveira,C Oliveira,Oliveira Isq.,A Oommen-Jose,A Oosthuizen,P J O’Reilly,P J O'Reilly,P Osborne,Owen Drj.,L Owen,Daniel R Owens,N Owino,M Pacurar,Paiva Bvb.,Palhares Emf.,S Palmer,Parracho Hmrt.,K Parsons,Darshana Patel,Brij Patel,F Patel,M Patrick-Smith,Ruth O. Payne,Y Peng,E J Penn,A Pennington,M P Peralta Alvarez,B P Pereira Stuchi,A L Perez,T Perinpanathan,J Perring,R Perumal,S Y Petkar,T Philip,J Phillips,M K Phohu,L Pickup,S Pieterse,J M Pinheiro,J Piper,D Pipini,M Plank,S Plant,S Pollard,Jennifer Pooley,A Pooran,Ian D. Poulton,Claire Powers,F B Presa,Delyth Price,V Price,M R Primeira,P C Proud,Samuel Provstgaard-Morys,S Pueschel,David Pulido,S Quaid,R Rabara,K Radia,D Rajapaska,T Rajeswaran,L Ramos,Ramos Asf.,F Ramos Lopez,Tommy Rampling,J Rand,H Ratcliffe,Thomas A. Rawlinson,D Rea,B Rees,M Resuello-Dauti,E Reyes Pabon,S Rhead,Tawassal Riaz,Marivic Ricamara,A Richards,A Richter,Neil D. Ritchie,A J Robbins,H Roberts,R E Robinson,S Roche,Christine S. Rollier,Louisa Rose,A L Ross Russell,L Rossouw,S Royal,I Rudiansyah,K Ryalls,C Sabine,Stephen Saich,J C Sale,Ahmed M. Salman,N Salvador,S Salvador,Sampaio,Adel Samson,A Sanchez-Gonzalez,H Sanders,K Sanders,E Santos,Santos Guerra Mfs.,I Satti,J E Saunders,Caroline Saunders,Sayed Aba.,I Schim van der Loeff,Annina B. Schmid,E Schofield,Gavin R. Screaton,S Seddiqi,R R Segireddy,R Senger,S Serrano,Imam Shaik,Hannah Sharpe,Katherine Sharrocks,R Shaw,A Shea,E Sheehan,A Shepherd,F Shiham,S E Silk,L Silva-Reyes,Silveira Lbtd.,Silveira Mbv.,Nishanta Singh,J Sinha,D T Skelly,David Smith,Nikki Smith,H E Smith,D J Smith,Catherine C. Smith,A S Soares,C Solórzano,G L Sorio,K Sorley,T Sosa-Rodriguez,Souza Cmcdl.,Souza Bsdf.,A R Souza,T Souza Lopez,L Sowole,Alexandra J. Spencer,L Spoors,L Stafford,I Stamford,R Stein,Lisa Stockdale,L V Stockwell,L H Strickland,Arabella Stuart,A Sturdy,N Sutton,A Szigeti,Abdessamad Tahiri-Alaoui,R Tanner,C Taoushanis,Alexander W. Tarr,R Tarrant,Kathryn Mary Taylor,U Taylor,Iona J. Taylor,J Taylor,R te Water Naude,Kate Templeton,Yrene Themistocleous,Andreas C. Themistocleous,Mark G. Thomas,Kelly M. Thomas,T M Thomas,Asha Thombrayil,John R. Thompson,Fiona M. Thompson,Amber J. Thompson,K Thompson,V Thornton-Jones,Thotusi Lhs.,Patrick J. Tighe,L A Tinoco,G F Tiongson,B Tladinyane,M Tomasicchio,Adriana Tomic,Susan Tonks,J Towner,N Tran,J A Tree,G Trillana,C Trinham,R Trivett,A Truby,B L Tsheko,P Tubb,A Turabi,Richard Turner,C Turner,Nicola Turner,B Tyagi,Marta Ulaszewska,B R Underwood,S van Eck,R Varughese,D Verbart,M K Verheul,Iason Vichos,T A Vieira,G Walker,Laura L. Walker,M E Wand,T Wardell,George M. Warimwe,Simon Warren,B Watkins,Watson Mee.,E Watson,S Webb,Andrew R. Webster,J Welch,Z Wellbelove,J H Wells,A J West,Beth White,Catherine White,Rachel White,P Williams,Rachel Williams,S Willingham,R Winslow,D Woods,M Woodyer,A T Worth,Daniel B. Wright,M Wroblewska,A Yao,Yim Ytn.,M B Zambrano,R L Zimmer,D Zizi,P Zuidewind +766 more
TL;DR: The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks as discussed by the authors.
Journal ArticleDOI
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.
Katie J. Ewer,Jordan R. Barrett,Sandra Belij-Rammerstorfer,Hannah Sharpe,R Makinson,R Morter,Amy Flaxman,Daniel B. Wright,D Bellamy,M Bittaye,Christina Dold,Nicholas M. Provine,J Aboagye,J Fowler,Sarah E. Silk,Jennifer Alderson,Parvinder K. Aley,Brian Angus,Eleanor Berrie,S Bibi,P Cicconi,Elizabeth A. Clutterbuck,Irina Chelysheva,P M Folegatti,Michelle Fuskova,Catherine M. Green,D Jenkin,S Kerridge,Alison M. Lawrie,Angela M. Minassian,Maria Moore,Y Mujadidi,E Plested,Ian D. Poulton,M N Ramasamy,Hannah Robinson,R Song,Matthew D. Snape,R Tarrant,Merryn Voysey,Watson Mee.,Alexander D. Douglas,Hill Avs.,Sarah C. Gilbert,Andrew J. Pollard,Teresa Lambe +45 more
TL;DR: Exploratory analyses of the immune responses in adults, aged 18-55 years, up to 8 weeks after vaccination with a single dose of ChAdOx1 nCoV-19 suggest a favorable immune profile induced by this vaccine candidate, supporting the progression of this vaccines candidate to ongoing phase 2/3 trials to assess vaccine efficacy.
Journal ArticleDOI
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses.
Jordan R. Barrett,Sandra Belij-Rammerstorfer,Christina Dold,Katie J. Ewer,P M Folegatti,Ciaran Gilbride,R Halkerston,Jennifer Hill,D Jenkin,Lisa Stockdale,M K Verheul,Parvinder K. Aley,Brian Angus,D Bellamy,Eleanor Berrie,S Bibi,M Bittaye,Miles W. Carroll,Breeze E. Cavell,Elizabeth A. Clutterbuck,Nick J. Edwards,Amy Flaxman,Michelle Fuskova,Andrew Gorringe,Bassam Hallis,S Kerridge,Alison M. Lawrie,A Linder,X Liu,M Madhavan,R Makinson,Jack Mellors,Angela M. Minassian,Maria Moore,Y Mujadidi,E Plested,Ian D. Poulton,M N Ramasamy,Hannah Robinson,Christine S. Rollier,R Song,Matthew D. Snape,R Tarrant,Stephen Taylor,Kelly M. Thomas,Merryn Voysey,Watson Mee.,Daniel B. Wright,Alexander D. Douglas,Catherine M. Green,Hill Avs.,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard +53 more
TL;DR: It is demonstrated that a booster dose of ChAdOx1 nCoV-19 is safe and better tolerated than priming doses, and anti-spike neutralizing antibody titers, as well as Fc-mediated functional antibody responses, including antibody-dependent neutrophil/monocyte phagocytosis, complement activation and natural killer cell activation, are substantially enhanced by a booster doses of vaccine.
Journal ArticleDOI
Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002).
Amy Flaxman,N G Marchevsky,D Jenkin,J Aboagye,Parvinder K. Aley,Brian Angus,Sandra Belij-Rammerstorfer,S Bibi,M Bittaye,Federica Cappuccini,P Cicconi,Elizabeth A. Clutterbuck,Sophie Davies,Wanwisa Dejnirattisai,Christina Dold,Katie J. Ewer,P M Folegatti,Jamie Fowler,Adrian V. S. Hill,Simon Kerridge,Angela M. Minassian,Juthathip Mongkolsapaya,Yama F Mujadidi,Emma Plested,M N Ramasamy,Hannah Robinson,Helen Sanders,Emma V. Sheehan,Holly Smith,Matthew D. Snape,R Song,Danielle Woods,Gavin R. Screaton,Sarah C. Gilbert,Merryn Voysey,Andrew J. Pollard,Teresa Lambe,Syed Adlou,Robert Aley,Aabidah Ali,Rachel Anslow,Megan Baker,Phillip Baker,Jordan R. Barrett,Louise Bates,Kirsten Beadon,Rebecca Beckley,Jonathan Bell,D Bellamy,Amy Beveridge,Cameron Bissett,Luke Blackwell,Heather Bletchly,Amy Boyd,Alice Bridges-Webb,Charles H. Brown,Nicholas Byard,Susana Camara,Liliana Cifuentes Gutierrez,Andrea M. Collins,Rachel Cooper,Wendy E.M. Crocker,Thomas C. Darton,Hannah Davies,Judith Davies,Tesfaye Demissie,Claudio Di Maso,Tanya Dinesh,Francesca R. Donnellan,Alexander D. Douglas,Rachael Drake-Brockman,Christopher J A Duncan,Sean C. Elias,Katherine R. W. Emary,Mutjaba Ghulam Farooq,Saul N. Faust,Sally Felle,Daniela M. Ferreira,Carla Ferreira Da Silva,Adam Finn,Karen J. Ford,Emma Francis,Julie Furze,Michelle Fuskova,Eva P. Galiza,Ana Gibertoni Cruz,Leila Godfrey,Anna L. Goodman,Catherine M. Green,Christopher A Green,Nicola Greenwood,Daisy Harrison,Thomas C. Hart,Sophia Hawkins,Paul T. Heath,Helen Hill,Kushalinii Hillson,Bryn Horsington,Mimi M. Hou,E Howe,Nicola Howell,Carina Citra Dewi Joe,Elizabeth F Jones,Mwila Kasanyinga,Jade Keen,Sarah Kelly,David J. Kerr,Liaquat Khan,Baktash Khozoee,Jasmin Kinch,Patrick Kinch,Stanislava Koleva,Jonathan Kwok,Colin W. Larkworthy,Alison M. Lawrie,Rajeka Lazarus,Emily A. Lees,Grace Li,Vincenzo Libri,Patrick J. Lillie,Aline Linder,Fei Long,Raquel Lopez Ramon,Reece Mabbett,R Makinson,Spyridoula Marinou,Emma Marlow,Julia L. Marshall,O Mazur,Joanne McEwan,Alastair McGregor,Jolynne Mokaya,Ella Morey,Gertraud Morshead,Richard Morter,Jilly Muller,Philomena Mweu,Rabiullah Noristani,Nelly Owino,Marco Polo Peralta Alvarez,Abigail Platt,Katrina M Pollock,Ian D. Poulton,Samuel Provstgaard-Morys,David Pulido-Gomez,Matthew Rajan,Fernando Ramos Lopez,Adam J. Ritchie,Hannah Roberts,Christine S. Rollier,Indra Rudiansyah,Katherine Sanders,Jack E. Saunders,Samiullah Seddiqi,Hannah Sharpe,Robert Shaw,L Silva-Reyes,Nisha Singh,David J. Smith,Catherine C. Smith,Andrew Smith,Alexandra J. Spencer,Arabella Stuart,Rebecca K. Sutherland,Anna Szigeti,Karly Tang,Merin Thomas,Tonia M. Thomas,Amber Thompson,E. Thomson,Estée M. Török,Mark Toshner,Nguyen Tran,Rose Trivett,Iain Turnbull,Cheryl Turner,David P. J. Turner,Marta Ulaszewska,Iason Vichos,Laura L. Walker,Marion E. Watson,Conor Whelan,Rachel White,Sarah Williams,Chris Williams,Daniel B. Wright,Andy Yao +186 more
TL;DR: In this paper, the authors assessed the persistence of immunogenicity after a single dose of ChAdOx1 nCoV-19 (AZD1222), immunity after an extended interval (44-45 weeks) between the first and second dose, and response to a third dose as a booster given 28-38 weeks after the second dose.
Journal ArticleDOI
A Booster Dose Enhances Immunogenicity of the COVID-19 Vaccine Candidate ChAdOx1 nCoV-19 in Aged Mice.
Alyssa Silva-Cayetano,William S. Foster,Silvia Innocentin,Sandra Belij-Rammerstorfer,Alexandra J. Spencer,Oliver T. Burton,Sigrid Fra-Bido,Jia Le Lee,Nazia Thakur,Carina Conceicao,Daniel J Wright,Jordan R. Barrett,Nicola Evans-Bailey,Carly Noble,Dalan Bailey,Adrian Liston,Sarah C. Gilbert,Teresa Lambe,Michelle A. Linterman +18 more
TL;DR: This study shows that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice, and suggests a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.