K
Kristine A. Kuhn
Researcher at University of Colorado Denver
Publications - 62
Citations - 3822
Kristine A. Kuhn is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Medicine & Autoantibody. The author has an hindex of 18, co-authored 47 publications receiving 2741 citations. Previous affiliations of Kristine A. Kuhn include University of Colorado Boulder & Boston Children's Hospital.
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Journal ArticleDOI
Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function
Caleb J. Kelly,Leon Zheng,Eric L. Campbell,Bejan Saeedi,Carsten C. Scholz,Amanda Bayless,Kelly Wilson,Louise E. Glover,Douglas J. Kominsky,Aaron Magnuson,Tiffany L. Weir,Stefan F. Ehrentraut,Stefan F. Ehrentraut,Christina Pickel,Kristine A. Kuhn,Jordi M. Lanis,Vu Nguyen,Cormac T. Taylor,Sean P. Colgan +18 more
TL;DR: A mechanism where host-microbe interactions augment barrier function in the distal gut is highlighted, where the influences of butyrate are lost in cells lacking HIF, thus linkingbutyrate metabolism to stabilized HIF and barrier function.
Journal ArticleDOI
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
Kristine A. Kuhn,Liudmila Kulik,Beren H. Tomooka,Kristin J. Braschler,William P. Arend,William H. Robinson,V. Michael Holers +6 more
TL;DR: It is demonstrated that antibodies against citrullinated proteins are centrally involved in the pathogenesis of autoimmune arthritis.
Journal ArticleDOI
Genetic and environmental risk factors for rheumatoid arthritis
Kevin D. Deane,M. Kristen Demoruelle,Lindsay B. Kelmenson,Kristine A. Kuhn,Jill M. Norris,V. Michael Holers +5 more
TL;DR: A major challenge to the field will be to investigate the full spectrum of the development of RA, from initiation and propagation of autoimmunity during preclinical RA and transition to clinically apparent synovitis and classifiable RA, to determine which genetic and environmental factors are important at each stage of disease development.
Journal ArticleDOI
Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis
Ted R. Mikuls,Jeffrey B. Payne,Richard A. Reinhardt,Geoffrey M. Thiele,Eileen K Maziarz,Amy C. Cannella,V. Michael Holers,Kristine A. Kuhn,James R. O'Dell +8 more
TL;DR: In this paper, the authors measured the antibody titers to P. gingivalis (a pathogen in periodontitis) in subjects with RA, PD, and in healthy controls and examined their relationship with disease autoantibodies.
Journal ArticleDOI
IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury
TL;DR: The data demonstrate the important role of IL-6 produced in part by intraepithelial lymphocytes at the onset of an inflammatory injury for epithelial proliferation and wound repair.