Jorge Boczkowski

TL;DR: The use of MTT assay on THP-1 cells exposed for 24 hours appears to be the most sensitive experimental design to assess the cytotoxic effect of one nanoparticle, and Copper- and Zinc-based nanoparticles appear to beThe most toxic.

TL;DR: It is concluded that mechanical ventilation for 48 h in rats produces a selective force reduction in the diaphragm.

TL;DR: Findings indicate that bilirubin can act as an effective agent to reduce mortality and counteract hypotension elicited by endotoxin through mechanisms involving a decreased NOS2 induction secondary to inhibition of NAD(P)H oxidase.

TL;DR: A recently identified carbon monoxide-releasing molecule, [Ru(CO)3Cl2]2 (or CORM-2), inhibits NAD(P)H oxidase cytochrome b558 activity, increases oxidant production by the mitochondria, and inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1, two critical pathways involved in muscle proliferation.

TL;DR: Telomere dysfunction and premature P-EC senescence are major processes perpetuating lung inflammation in COPD.