J
Jorge Rodrigues de Sousa
Researcher at Federal University of Pará
Publications - 47
Citations - 4001
Jorge Rodrigues de Sousa is an academic researcher from Federal University of Pará. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 12, co-authored 37 publications receiving 3638 citations. Previous affiliations of Jorge Rodrigues de Sousa include Evandro Chagas Institute.
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In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda do Socorro da Silva Azevedo,Jorge Rodrigues de Sousa,Marialva Tereza Ferreira de Araújo,Arnaldo Jorge Martins Filho,Bianca Nascimento de Alcantara,Fernanda Montenegro de Carvalho Araújo,Maria G. L. Queiroz,Ana Cecília Ribeiro Cruz,Beatriz H. Baldez Vasconcelos,Jannifer Oliveira Chiang,Lívia Carício Martins,Livia Medeiros Neves Casseb,Eliana Vieira Pinto da Silva,Valéria Lima Carvalho,Barbara Cristina Baldez Vasconcelos,Sueli Rodrigues,Consuelo Silva de Oliveira,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos +18 more
TL;DR: The in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases were investigated and changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and inflammatory infiltration of mononuclear cells.
Journal ArticleDOI
Leprosy As a Complex Infection: Breakdown of the Th1 and Th2 Immune Paradigm in the Immunopathogenesis of the Disease.
Jorge Rodrigues de Sousa,Mirian Nacagami Sotto,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma +3 more
TL;DR: The role of these new subtypes of T helper lymphocytes and how the development of the immune response of these cells modifies the pattern of the Th1/Th2 response in the immunopathogenesis of leprosy are discussed.
Journal ArticleDOI
In situ expression of M2 macrophage subpopulation in leprosy skin lesions.
Jorge Rodrigues de Sousa,Raphael Primo Martins de Sousa,Tinara Leila de Souza Aarão,Tinara Leila de Souza Aarão,Leônidas Braga Dias,Francisca Regina Oliveira Carneiro,Hellen Thais Fuzii,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma +8 more
TL;DR: Response of M2 macrophages emerge as an alternative for a better understanding of the innate immunity in the polar forms of leprosy, highlighting the role of cytokines, arginase 1 and costimulatory molecules in the repair and suppressive responses in the lepromatous form of the disease.
Journal ArticleDOI
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases
Jorge Rodrigues de Sousa,Raimunda do Socorro da Silva Azevedo,Arnaldo Jorge Martins Filho,Marialva Tereza Ferreira de Araújo,Ermelinda do Rosário Moutinho da Cruz,Barbara Cristina Baldez Vasconcelos,Ana Cecília Ribeiro Cruz,Consuelo Silva de Oliveira,Lívia Carício Martins,Beatriz H. Baldez Vasconcelos,Livia Medeiros Neves Casseb,Jannifer Oliveira Chiang,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos,Pedro Fernando da Costa Vasconcelos +14 more
TL;DR: It is suggested that inflammasome activation can aggravate the neuroinflammatory response and consequently increase CNS damage in neonates with fetal neural ZIKV infection and microcephaly.
Journal ArticleDOI
Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update.
Tinara Leila de Souza Aarão,Jorge Rodrigues de Sousa,Aline Semblano Carreira Falcão,Luiz Fábio Magno Falcão,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma +6 more
TL;DR: The analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection, which is one of the main causes of infection in the peripheral nervous system.