Showing papers in "Cytokine in 2018"

TL;DR: A prominent pro‐inflammatory Th1 and Th17 response was clearly seen in patients with MERS‐CoV infection, with markedly increased concentrations of IFN‐&ggr;, TNF‐&agR;, IL‐15 and IL‐17 compared to controls.

TL;DR: Old and new data on the importance of TNF produced by T cells are reviewed and how TNF signaling via TNFR2 may directly impact alternate aspects of T cell biology are reviewed.

TL;DR: Although monoclonal full IgG1 antibodies are able to induce clinical and endoscopic remission in inflammatory bowel diseases, certolizumab pegol without Fc portion has been shown to be less effective forinflammatory bowel diseases compared to full Igg1 antibodies.

TL;DR: The current knowledge of TNF signaling is described and its relevance for human health is described, including its role in immune responses in healthy organisms and in diseased conditions.

TL;DR: This review focuses on a key chemokine named CXCL10 and its role in directing the migratory propertied and biological function of CD4+ and CD8+ T cells in the context of cancer and inflammatory autoimmunity and summarizes the findings and their potential translational implication.

TL;DR: First evidence is provided that melanoma exosomes can induce a mixed M1 and M2 pro‐tumor macrophage activation phenotype, as well as a trend toward increased i‐NOS (M1) to arginase (M2) activity.

TL;DR: Recent studies of PGRN as a novel target molecule in the field of autoimmune disease are summarized, and updated information to inspire future studies are provided.

TL;DR: neutralizing the interaction of CXCL12/CXCR4 with a variety of antagonists induced apoptosis and differentiation and increased the chemosensitivity of lymphoma, myeloma, and leukemia cells.

TL;DR: Examination of the relationship between TBI symptoms and changes in pro‐ and anti‐ inflammatory biomarkers found increased levels of interleukin (IL)‐6, IL1, IL8, IL10 and tumor necrosis factor alpha (TNF&agr;) were associated with worse outcomes, with most studies focusing on mortality and mortality.

TL;DR: Recent studies suggesting that, despite early misconceptions that these proteins are pathogenic, RELM proteins have a more nuanced and potentially beneficial role for the host in certain disease settings are discussed.

TL;DR: The results showed that IL‐1&bgr;; IL‐6 and IL‐8 causes hypercoagulation and results in a disheveled fibrin clot, with trapped RBCs, which is a novel finding.

TL;DR: In this article, the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS) were explored, and they evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24-weeks of moderate aerobic exercise in sedentary IBS patients.

TL;DR: Given that the IL‐17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti‐IL‐23/IL‐17 agents seem to be superior to anti‐TNF‐&agr; remedies in the treatment of skin lesions.

TL;DR: Treatment with TNFi is not associated with increased malignant risks of overall cancer, lymphoma or melanoma and results of NMSC risk were inconsistent among studies.

TL;DR: Further evidences for dysregulation of immune response in ASD patients are provided and no significant difference has been found in expression levels of other cytokines between patients and healthy subjects.

TL;DR: The study suggests that luteolin showed attenuation in sepsis‐induced acute lung injury in mice through suppression in ICAM‐1, NF‐kappa B, oxidative stress and partially iNOS pathways.

TL;DR: CXCL12 and its receptors CXCR4 and ACKR3 provide extraordinary examples of multisystem multitasking in the chemokine system in both health and disease.

TL;DR: Treatment of asthma patients with vitamin D reduced respiratory infections, and this effect was related to the increase of cathelicidin LL‐37, which causes a decrease in colonization by pathogenic bacteria in airway.

TL;DR: Although there was a trend for post‐exercise cortisol to be decreased following both heat acclimation programmes (chronic effects), there were no within or between intervention differences in IL‐6 or CRP.

TL;DR: In this paper, a review of knowledge on how TNFα modulates T cell responses and the effect of engaging either of its two membrane-bound receptors is presented, and the authors discuss how such interactions can dictate the outcome of treatment with TNFβ inhibitors.

TL;DR: Atypical chemokine receptor 3 (ACKR3) has proven to be an important receptor in mediating normal biological functions, including cardiac development and migration of cortical neurons, and is illustrated in this review.

TL;DR: The mechanisms by which cytokines promote therapeutic resistance of BCa are discussed and a potential approach for improving BCa therapeutics by inhibition of exosome function is suggested.

TL;DR: This review summarises the knowledge on macrophage‐mediated inflammation, its impact on a cell’s metabolic activity and its effect on osteoclast differentiation.

TL;DR: The impact of short‐term HIIT and MICT resulted in differential effects on anti‐inflammatory cytokine function, indicating that measuring anti‐ inflammatory cytokine action could reveal important immunomodulatory effects of exercise.

TL;DR: It is suggested that inflammasome activation can aggravate the neuroinflammatory response and consequently increase CNS damage in neonates with fetal neural ZIKV infection and microcephaly.

TL;DR: The biology and pathophysiologic role of TNF; and on the therapeutic implications of targeting TNF‐&agr; receptor signalling are focused on.

TL;DR: Its high constitutive expression levels and its further up‐regulation in many diseases, together with its moderate chemoattractant properties support the fact that this chemokine has activities beyond cell recruitment.

TL;DR: It is shown that one of these cytokines, CXCL1, potently antagonizes in vivo muscle regeneration and interferes with in vivo Muscle satellite cell homeostasis and highlights the pleiotropic nature of a novel tumor‐derived cytokine and underscores the importance of cytokines in muscle progenitor cell regulation.

TL;DR: The IL‐12 family is discussed, focusing on IL‐27 and IL‐35 during anti‐fungal immune responses to pathogens such as Candida and Aspergillus.

TL;DR: This review reports how post-translational modification (PTM) influence the biological functions of chemokines, with special attention for the impact beyond chemotaxis.