Journal ArticleDOI
In situ expression of M2 macrophage subpopulation in leprosy skin lesions.
Jorge Rodrigues de Sousa,Raphael Primo Martins de Sousa,Tinara Leila de Souza Aarão,Tinara Leila de Souza Aarão,Leônidas Braga Dias,Francisca Regina Oliveira Carneiro,Hellen Thais Fuzii,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma +8 more
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TLDR
Response of M2 macrophages emerge as an alternative for a better understanding of the innate immunity in the polar forms of leprosy, highlighting the role of cytokines, arginase 1 and costimulatory molecules in the repair and suppressive responses in the lepromatous form of the disease.About:
This article is published in Acta Tropica.The article was published on 2016-05-01. It has received 39 citations till now. The article focuses on the topics: Lepromatous leprosy & Tuberculoid leprosy.read more
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Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.
TL;DR: The immunosuppressive status of the tumor microenvironment (TME) remains poorly defined and emerging evidence highlighting the redefinition of TAM subpopulations and functions in the TME and the possibility of separating macrophage subsets with distinct functions into antitumor M1-like and pro-tumors M2-like TAMs during the development of tumors is discussed.
Journal ArticleDOI
Innate Immune Responses in Leprosy.
Roberta Olmo Pinheiro,Veronica Schmitz,Bruno Jorge de Andrade Silva,André Alves Dias,Beatriz Junqueira de Souza,Mayara Garcia de Mattos Barbosa,Danuza de Almeida Esquenazi,Maria Cristina Vidal Pessolani,Euzenir Nunes Sarno +8 more
TL;DR: Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management.
Journal ArticleDOI
Leprosy As a Complex Infection: Breakdown of the Th1 and Th2 Immune Paradigm in the Immunopathogenesis of the Disease.
Jorge Rodrigues de Sousa,Mirian Nacagami Sotto,Juarez Antônio Simões Quaresma,Juarez Antônio Simões Quaresma +3 more
TL;DR: The role of these new subtypes of T helper lymphocytes and how the development of the immune response of these cells modifies the pattern of the Th1/Th2 response in the immunopathogenesis of leprosy are discussed.
Journal ArticleDOI
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis.
Ricardo Luis Louzada da Silva,Márcio Bezerra Santos,Priscila Lima dos Santos Almeida,Thayse S. Barros,Lucas Sousa Magalhães,Rodrigo Anselmo Cazzaniga,Patricia Rodrigues Marques de Souza,Nívea F. Luz,Jaqueline França-Costa,Valéria M. Borges,Djalma S. Lima-Junior,Michael W. Lipscomb,Malcolm S. Duthie,Steven G. Reed,Roque P. Almeida,Amélia Ribeiro Jesus +15 more
TL;DR: Results reveal sCD163 as a potential biomarker of severity of diseases caused by intracellular pathogens M. leprae and Leishmania spp.
Journal ArticleDOI
Type I Interferons, Autophagy and Host Metabolism in Leprosy.
Thiago Gomes de Toledo Pinto,Leonardo Ribeiro Batista-Silva,Rychelle Clayde Affonso Medeiros,Flávio Alves Lara,Milton Ozório Moraes +4 more
TL;DR: New pathways involved in the early mycobacteria–host interaction that regulate innate immune pathways or metabolism and could be new targets to host therapy strategies are discussed.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
Journal ArticleDOI
Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
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Katherine Antunes de Mattos,Viviane Carneiro Gonçalves Oliveira,Marcia Berrêdo-Pinho,Julio J. Amaral,Luis Caetano M. Antunes,Rossana C. N. Melo,Chyntia Carolina Diaz Acosta,Danielle F. Moura,Roberta Olmo,Jun Han,Patrícia Sammarco Rosa,Patrícia E. Almeida,Patrícia E. Almeida,B. Brett Finlay,Christoph H. Borchers,Euzenir Nunes Sarno,Patrícia T. Bozza,Georgia C. Atella,Maria Cristina Vidal Pessolani +18 more