Joris van de Haar

TL;DR: A platform to induce and analyze tumor-specific T cell responses to epithelial cancers in a personalized manner is established and co-cultures of autologous tumor organoids and peripheral blood lymphocytes can be used to enrich tumor-reactive T cells from peripheral blood of patients with mismatch repair-deficient colorectal cancer and non-small-cell lung cancer.

TL;DR: An in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care chemotherapy in colorectal cancer (CRC) is developed and the feasibility of generating and testing PDOs for evaluation of sensitivity to chemotherapy is shown.

TL;DR: How the seven comprehensive cancer centers of Cancer Core Europe have organized their healthcare systems at an unprecedented scale and pace to make their operations ‘pandemic proof’ is reported.

TL;DR: The paper describes the molecular profiling results, given recommendations and clinical trial enrolment of 895 patients reviewed by the GRB, and shares the challenges encountered during the establishment of theGRB.

TL;DR: In this article, the authors analyzed whole-genome sequencing (WGS) data of 250 biopsy pairs, longitudinally collected over the treatment course of 231 adult patients with a representative variety of metastatic solid malignancies.