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Xavier Saelens
Researcher at Ghent University
Publications - 221
Citations - 12881
Xavier Saelens is an academic researcher from Ghent University. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 54, co-authored 201 publications receiving 11070 citations. Previous affiliations of Xavier Saelens include Flanders Institute for Biotechnology & University of Helsinki.
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Journal ArticleDOI
Toxic proteins released from mitochondria in cell death
Xavier Saelens,Nele Festjens,Lieselotte Vande Walle,Maria van Gurp,Geert van Loo,Geert van Loo,Peter Vandenabeele +6 more
TL;DR: The precise mode of action and importance of cytochrome c in apoptosis in mammalian cells has become clear through biochemical, structural and genetic studies, and more recently identified factors, for example HtrA2/OMI and Smac/DIABLO, are still being studied intensively in order to delineate their functions in apoptoses.
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A universal influenza A vaccine based on the extracellular domain of the M2 protein.
TL;DR: The enhanced immunogenicity of the M2 extracellular domain exposed on HBc particles allows broad-spectrum, long-lasting protection against influenza A infections.
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The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
TL;DR: This review summarises and evaluates the current knowledge concerning the complex role of released mitochondrial proteins in the apoptotic process and identifies members of the Bcl-2 protein family that control the integrity and response of mitochondria to apoptotic signals.
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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Daniel Wrapp,Dorien De Vlieger,Kizzmekia S. Corbett,Gretel M. Torres,Nianshuang Wang,Wander Van Breedam,Kenny Roose,Loes van Schie,Markus Hoffmann,Stefan Pöhlmann,Barney S. Graham,Nico Callewaert,Bert Schepens,Xavier Saelens,Jason S. McLellan +14 more
TL;DR: The isolation of single-domain antibodies (VHHs) from a llama immunized with prefusion-stabilized coronavirus spikes provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronav virus outbreaks.
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Mitochondrial intermembrane proteins in cell death.
TL;DR: The role of cytochrome c, AIF, endonuclease G, Smac/DIABLO, Omi/HtrA2, Acyl-CoA-binding protein, and polypyrimidine tract-bindingprotein in the initiation and modulation of cell death in different model organisms is focused on.