John E. Hale

TL;DR: In this paper, a truncated inactive protein was found to suppress food intake and decrease body weight in normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor.

TL;DR: The identification and characterization of human GOAT is reported, the ghrelin O-acyl transferase, the only known protein modified with an O-linked octanoyl side group, which occurs on its third serine residue, and it is demonstrated the relevance of GOAT in the acylation of Ghrelin and further implicates acylated gh Relin in pancreatic function.

TL;DR: The crystal structure at 2.4 Å resolution of a human mutant OB protein (leptin-E100) is reported that has comparable biological activity to wild type but which crystallizes more readily and reveals a four-helix bundle similar to that of the long-chain helical cytokine family.

TL;DR: Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of LPL.

TL;DR: Ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylated substrates and links ingested lipids to energy expenditure and body fat mass.