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Konstantinos Chiotis
Researcher at Karolinska Institutet
Publications - 47
Citations - 2480
Konstantinos Chiotis is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Dementia & Positron emission tomography. The author has an hindex of 21, co-authored 40 publications receiving 1788 citations. Previous affiliations of Konstantinos Chiotis include Karolinska University Hospital & Stockholm County Council.
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Journal ArticleDOI
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
Giovanni B. Frisoni,Marina Boccardi,Frederik Barkhof,Kaj Blennow,Kaj Blennow,Stefano F. Cappa,Stefano F. Cappa,Konstantinos Chiotis,Jean-François Démonet,Valentina Garibotto,Panteleimon Giannakopoulos,Anton F. Gietl,Oskar Hansson,Karl Herholz,Clifford R. Jack,Flavio Nobili,Flavio Nobili,Agneta Nordberg,Agneta Nordberg,Heather M. Snyder,Mara ten Kate,Andrea Varrone,Emiliano Albanese,Stefanie I. Becker,Patrick M.M. Bossuyt,Maria C. Carrillo,Chiara Cerami,Bruno Dubois,Valentina Gallo,Ezio Giacobini,Gabriel Gold,Samia Hurst,Anders Lönneborg,Karl-Olof Lövblad,Niklas Mattsson,José-Luis Molinuevo,Andreas U. Monsch,Urs Peter Mosimann,Alessandro Padovani,Agnese Picco,Agnese Picco,Corinna Porteri,Osman Ratib,Laure Saint-Aubert,Charles Scerri,Charles Scerri,Philip Scheltens,Jonathan M. Schott,Ida Sonni,Ida Sonni,Stefan J. Teipel,Stefan J. Teipel,Paolo Vineis,Pieter Jelle Visser,Pieter Jelle Visser,Yutaka Yasui,Bengt Winblad,Bengt Winblad +57 more
TL;DR: A strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers is developed.
Journal ArticleDOI
Tau PET imaging in neurodegenerative tauopathies—still a challenge
Antoine Leuzy,Konstantinos Chiotis,Konstantinos Chiotis,Laetitia Lemoine,Per-Göran Gillberg,Ove Almkvist,Ove Almkvist,Elena Rodriguez-Vieitez,Agneta Nordberg,Agneta Nordberg +9 more
TL;DR: Findings from in vitro and in vivo studies using both initial and new tau ligands are described and discussed, including their relation to biomarkers for amyloid-β and neurodegeneration, and cognitive findings.
Journal ArticleDOI
Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease
Elena Rodriguez-Vieitez,Laure Saint-Aubert,Stephen F. Carter,Ove Almkvist,Ove Almkvist,Ove Almkvist,Karim Farid,Michael Schöll,Konstantinos Chiotis,Steinunn Thordardottir,Steinunn Thordardottir,Caroline Graff,Caroline Graff,Anders Wall,Bengt Långström,Agneta Nordberg,Agneta Nordberg +16 more
TL;DR: Rodriguez-Vieitez et al. as mentioned in this paper showed that progression of Alzheimer's disease in a longitudinal, multi-racer PET study showed that the relationship between pathophysiological processes in the disease remains largely unclear.
Journal ArticleDOI
Tau PET imaging: present and future directions.
Laure Saint-Aubert,Laetitia Lemoine,Konstantinos Chiotis,Antoine Leuzy,Elena Rodriguez-Vieitez,Agneta Nordberg,Agneta Nordberg +6 more
TL;DR: Recent findings on the most promising tau PET tracers to date are summarized, what has been learnt is discussed, and some suggestions for the next steps that need to be achieved in a near future are offered.
Journal ArticleDOI
Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm
Konstantinos Chiotis,Laure Saint-Aubert,Irina Savitcheva,Vesna Jelic,Pia Andersen,My Jonasson,My Jonasson,Jonas Eriksson,Jonas Eriksson,Mark Lubberink,Ove Almkvist,Ove Almkvist,Ove Almkvist,Anders Wall,Anders Wall,Gunnar Antoni,Gunnar Antoni,Agneta Nordberg,Agneta Nordberg +18 more
TL;DR: The tau-specific PET tracer [18F]THK5317 images in vivo show the expected regional distribution of tau pathology, which contrasts with the different patterns of hypometabolism and amyloid-beta deposition.