Joseph Abecassis

TL;DR: It is concluded that the collagenase gene family in humans consists of at least four members, and speculate that expression of these genes plays a role in cancer.

TL;DR: This study reports the first large-scale gene expression analysis of a unique HNSCC location, the hypopharynx, and identifies 164 differentially expressed genes potentially involved in the acquisition of metastatic potential.

TL;DR: There was a highly significant positive correlation between ST3 RNA levels and local invasiveness by the cancer cells, suggesting that enhanced expression of the ST3 gene may contribute to the neoplastic phenotype in head and neck carcinomas.

TL;DR: In head and neck squamous‐cell carcinomas, over‐expression of the 2 stromelysin genes and the type‐1 collagenase gene (but not the pump‐1 gene) is associated with a high degree of tumour differentiation, suggesting that theStromelysins may be implicated in the clinical course of head and head tumours.

TL;DR: Important criteria required to predict clinically active HPV infection are highlighted, new biological pathways implicated in HPV tumorigenesis are identified and the understanding of HPV‐HNSCC physiopathology is increased to develop new targets for therapy.