Journal ArticleDOI
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours.
Danièle Muller,R. Breathnach,A. Engelmann,Régine Millon,G. Bronner,H. Flesch,P. Dumont,Michel Eber,Joseph Abecassis +8 more
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TLDR
In head and neck squamous‐cell carcinomas, over‐expression of the 2 stromelysin genes and the type‐1 collagenase gene (but not the pump‐1 gene) is associated with a high degree of tumour differentiation, suggesting that theStromelysins may be implicated in the clinical course of head and head tumours.Citations
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Matrix metalloproteinases in skin
TL;DR: The role of MMPs and TIMPs in human skin based on new observations on the regulation of the expression of M MPs, on their substrate specificily, and MMP expression in physiologic and pathologic conditions of skin involving matrix remodeling are discussed.
Journal Article
The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis.
TL;DR: Evidence is reviewed which indicates that matrix metalloproteases and tissue inhibitors of metalliproteases are essential for tumour cell invasion and angiogenesis, and the mechanism for tissue inhibitor of metaloprotease-mediated inhibition of tumour invasion and Angiogenesis appears to be through inhibition of protease activity required for cellular invasion.
Journal ArticleDOI
Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions
TL;DR: Findings suggest that MAT may have a specific role in normal gland and organ function, a possibility which can be explored further by the genetic manipulation of MAT levels in vivo.
Journal ArticleDOI
The role of proteolytic enzymes in cancer invasion and metastasis.
TL;DR: It is concluded that certain proteases may be new prognostic markers in cancer as well as new targets for anti-metastatic therapy.
Journal ArticleDOI
Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer.
Erja Kerkelä,Ulpu Saarialho-Kere +1 more
TL;DR: The present role of MMPs in the development and progression of cancer, focusing on non‐melanoma skin cancers basal (BCC) and squamous (SCC) cell carcinoma, and the possible influence of M MPs in their differences is discussed.
References
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Journal ArticleDOI
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
Charles Auffray,François Rougeon +1 more
TL;DR: A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice by oligo(dT)-cellulose chromatography and either sucrose gradient centrifugation in conditions preventing aggregation or by means of high-resolution preparative gel electrophoresis under non-denaturing conditions.
Journal ArticleDOI
Metalloproteinases and their inhibitors in matrix remodeling.
TL;DR: Experiments designed to improve the understanding of metalloproteinase regulation have also resulted in new insights into mechanisms by which growth factors and proto-oncogenes may regulate biological processes.
Journal ArticleDOI
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
Paul Basset,Jean-Pierre Bellocq,Catherine Wolf,I. Stoll,P. Hutin,J. M. Limacher,Osvaldo L. Podhajcer,Chenard Mp,M. C. Rio,Pierre Chambon +9 more
TL;DR: The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
Journal ArticleDOI
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
Ivan E. Collier,Scott M. Wilhelm,Arthur Z. Eisen,Barry L. Marmer,Gregory A. Grant,Jo Louise Seltzer,Annemarie Kronberger,Chengshi He,Eugene A. Bauer,Gregory I. Goldberg +9 more
TL;DR: H-ras-transformed human bronchial epithelial cells (TBE-1) secrete a single major extracellular matrix metalloprotease which is not found in the normal parental cells, which is likely the human analog of type IV collagenase detected in several rodent tumors.
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Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line.
TL;DR: cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors.