J
Joseph Bryan
Researcher at Pacific Northwest Diabetes Research Institute
Publications - 122
Citations - 16624
Joseph Bryan is an academic researcher from Pacific Northwest Diabetes Research Institute. The author has contributed to research in topics: Sulfonylurea receptor & Potassium channel. The author has an hindex of 55, co-authored 121 publications receiving 16119 citations. Previous affiliations of Joseph Bryan include Baylor College of Medicine.
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Journal ArticleDOI
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Nobuya Inagaki,Tohru Gonoi,John P. Clement,Noriyuki Namba,Johji Inazawa,Gabriela Gonzalez,Lydia Aguilar-Bryan,Susumu Seino,Joseph Bryan +8 more
TL;DR: Gene mapping data indicate that these pancreatic β cell potassium channels are a complex composed of at least two subunits-BIR, a member of the inward rectifier potassium channel family, and SUR, a members of the ATP-binding cassette superfamily.
Journal ArticleDOI
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
Lydia Aguilar-Bryan,Colin G. Nichols,Sérgio W. Wechsler,John P. Clement,A. E. Boyd,Gabriela Gonzalez,Haydee Herrera-Sosa,Kimberly Nguy,Joseph Bryan,Daniel A. Nelson +9 more
TL;DR: The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release.
Journal ArticleDOI
A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels
Nobuya Inagaki,Tohru Gonoi,John P. Clement,Chang Zheng Wang,Lydia Aguilar-Bryan,Joseph Bryan,Susumu Seino +6 more
TL;DR: The present study shows that the ATP sensitivity and pharmacological properties of K(ATP) channels are determined by a family of structurally related but functionally distinct sulfonylurea receptors.
Journal ArticleDOI
Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
Pamela M. Thomas,Gilbert J. Cote,Nelson Wohllk,Bassem Haddad,P. M. Mathew,Wolfgang Rabl,Lydia Aguilar-Bryan,Robert F. Gagel,Joseph Bryan +8 more
TL;DR: Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene, a regulator of insulin secretion, mapped to 11p15.1 by means of fluorescence in situ hybridization.
Journal ArticleDOI
Association and Stoichiometry of KATP Channel Subunits
John P. Clement,Kumud Kunjilwar,Gabriela Gonzalez,Mathias Schwanstecher,Uwe Panten,Lydia Aguilar-Bryan,Joseph Bryan +6 more
TL;DR: In this article, the authors showed that a 1:1 SUR1:K IR 6.2 stoichiometry is both necessary and sufficient for assembly of active K ATP channels, and that a mixture of strongly and weakly rectifying triple fusion proteins, rescued by SUR1, produced the three channel types expected of a tetrameric pore.