Joseph Lin

TL;DR: The past several years have seen the beginning of a shift in the way that TCR signal transduction is studied, with the identification of distinct formations of signaling molecules at junctions between T cells and antigen-presenting cells, the role of the cytoskeleton and the partitioning of molecules into specialized lipid subdomains being the subjects of many publications.

TL;DR: The basic chemical biology of H2S as well as other related or derived species is discussed and reviewed, and this review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H 2S and which may be important biological effectors themselves.

TL;DR: A model in which the ngn3 gene is activated by the coordinated activities of several pancreatic transcription factors and inhibited by Notch signaling through HES1 is suggested, which suggests that the addition of distal sequences greatly enhances transgene expression.

TL;DR: Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the e, δ, γ and ζ subunits of theTCR.

TL;DR: Several lines of evidence indicate that the nuclear factor (NF)-kappaB pathway is perhaps the most relevant biochemical or transcriptional target for the costimulatory activity of CD28.