J
Joseph W. Ndieyira
Researcher at Jomo Kenyatta University of Agriculture and Technology
Publications - 14
Citations - 387
Joseph W. Ndieyira is an academic researcher from Jomo Kenyatta University of Agriculture and Technology. The author has contributed to research in topics: Cantilever & Signal. The author has an hindex of 7, co-authored 14 publications receiving 361 citations. Previous affiliations of Joseph W. Ndieyira include Royal Free Hospital & London Centre for Nanotechnology.
Papers
More filters
Journal ArticleDOI
Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance.
Joseph W. Ndieyira,Moyu Watari,Alejandra Donoso Barrera,Dejian Zhou,Dejian Zhou,Manuel Vögtli,Matthew Batchelor,Mark E. Cooper,Torsten Strunz,Michael A. Horton,Chris Abell,Trevor Rayment,Gabriel Aeppli,Rachel A. McKendry +13 more
TL;DR: The label-free detection of vancomycin binding to bacterial cell wall precursor analogues (mucopeptides) on cantilever arrays is reported, with 10 nM sensitivity and at clinically relevant concentrations in blood serum, placing BioMEMS devices in a new class of percolative systems.
Journal ArticleDOI
Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum.
Joseph W. Ndieyira,Natascha Kappeler,Stephen Logan,Mark E. Cooper,Chris Abell,Rachel A. McKendry,Gabriel Aeppli +6 more
TL;DR: The work reveals variations among strong and weak competing ligands, such as proteins in human serum, that determine dosages in drug therapies and will help develop better treatments, including choice of drugs as well as dosages, against pathogens.
Journal ArticleDOI
Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays.
Samadhan B. Patil,Manuel Vögtli,Benjamin L. J. Webb,Benjamin L. J. Webb,Giuseppe Mazza,Massimo Pinzani,Yeong-Ah Soh,Rachel A. McKendry,Joseph W. Ndieyira,Joseph W. Ndieyira +9 more
TL;DR: A way to immobilize membrane receptors on nanomechanical cantilevers so that they can function without passivating the underlying surface and offer a new way to sense biomolecules and will aid in the creation of ultrasensitive biosensors.
Journal ArticleDOI
Disentangling mechanical and mass effects on nanomechanical resonators
R. R. Grüter,Z. Khan,R. Paxman,Joseph W. Ndieyira,Benjamin Dueck,Benjamin A. Bircher,Jie Yang,Ute Drechsler,Michel Despont,Rachel A. McKendry,Bart W. Hoogenboom +10 more
TL;DR: In this paper, the authors demonstrate a procedure to disentangle this complex sensor response, to simultaneously measure both mass and elastic properties of nanometer thick samples, enabling them to measure more than mass alone.
Journal ArticleDOI
Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
Joseph W. Ndieyira,Joe Bailey,Samadhan B. Patil,Manuel Vögtli,Mark E. Cooper,Chris Abell,Rachel A. McKendry,Gabriel Aeppli +7 more
TL;DR: It is demonstrated that drug-target interactions are strengthened by pronounced polyvalent interactions catalyzed by the surface itself, which further enhance the understanding of antibiotic mode of action and will enable development of more effective therapies.