J
Josephine M. Forbes
Researcher at University of Queensland
Publications - 226
Citations - 16827
Josephine M. Forbes is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Glycation. The author has an hindex of 59, co-authored 220 publications receiving 14581 citations. Previous affiliations of Josephine M. Forbes include Royal Children's Hospital & University of New South Wales.
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Journal ArticleDOI
Mechanisms of Diabetic Complications
TL;DR: The well validated, as well as putative mechanisms involved in the development of diabetic complications are discussed and new fields of research, which warrant further investigation as potential therapeutic targets of the future, will be highlighted.
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Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
TL;DR: There is now an increasing body of data to suggest that strategies involving a more targeted antioxidant approach, using agents that penetrate specific cellular compartments, may be the elusive additive therapy required to further optimize renoprotection in diabetes.
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Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
Matthew D Oldfield,Leon A. Bach,Josephine M. Forbes,David J. Nikolic-Paterson,Anne McRobert,Vicki Thallas,Robert C. Atkins,Tanya M. Osicka,George Jerums,Mark E. Cooper +9 more
TL;DR: This study provides a novel mechanism to explain the development of tubulointerstitial disease in diabetic nephropathy and provides a new treatment target.
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A Breaker of Advanced Glycation End Products Attenuates Diabetes-Induced Myocardial Structural Changes
Riccardo Candido,Josephine M. Forbes,Merlin C. Thomas,Vicki Thallas,Rachael G Dean,Wendy C. Burns,Christos Tikellis,Rebecca H. Ritchie,Stephen M. Twigg,Mark E. Cooper,Louise M Burrell +10 more
TL;DR: It is suggested that AGEs play a central role in many of the alterations observed in the diabetic heart and that cleavage of preformed AGE crosslinks with ALT‐711 leads to attenuation of diabetes‐associated cardiac abnormalities in rats.
Journal ArticleDOI
Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
Angelika Bierhaus,Thomas Fleming,S. B. Stoyanov,Andreas Leffler,Andreas Leffler,Alexandru Babes,Alexandru Babes,Cristian Neacsu,Susanne K. Sauer,Mirjam Eberhardt,Martina Schnölzer,Felix Lasischka,Winfried Neuhuber,Tatjana I. Kichko,Ilze Konrade,Ralf Elvert,Walter Mier,Valdis Pirags,Ivan K. Lukic,Michael Morcos,Thomas Dehmer,Naila Rabbani,Paul J. Thornalley,Diane Edelstein,Carla Nau,Josephine M. Forbes,Per M. Humpert,Markus Schwaninger,Dan Ziegler,David M. Stern,Mark E. Cooper,Uwe Haberkorn,Michael Brownlee,Peter W. Reeh,Peter P. Nawroth +34 more
TL;DR: It is found that concentrations of plasma methylglyoxal above 600 nM discriminate between diabetes-affected individuals with pain and those without pain, which provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy.