J
Joshua B. Sheetz
Researcher at Yale University
Publications - 10
Citations - 191
Joshua B. Sheetz is an academic researcher from Yale University. The author has contributed to research in topics: Kinase & Receptor tyrosine kinase. The author has an hindex of 5, co-authored 8 publications receiving 111 citations. Previous affiliations of Joshua B. Sheetz include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.
Brandon M. Gassaway,Max C. Petersen,Max C. Petersen,Yulia V. Surovtseva,Karl W. Barber,Joshua B. Sheetz,Hans R. Aerni,Jane S. Merkel,Varman T. Samuel,Gerald I. Shulman,Gerald I. Shulman,Jesse Rinehart +11 more
TL;DR: An expanded set of proteins through which PKCε may drive high-fat diet-induced hepatic insulin resistance that may direct new therapeutic approaches for T2D are identified.
Journal ArticleDOI
RGS Proteins and Septins Cooperate to Promote Chemotropism by Regulating Polar Cap Mobility
Joshua B. Kelley,Gauri Dixit,Joshua B. Sheetz,Sai Phanindra Venkatapurapu,Timothy C. Elston,Henrik G. Dohlman +5 more
TL;DR: It is shown that septins colocalize with the regulator of G protein signaling (RGS) Sst2, a GTPase-activating protein that dampens pheromone receptor signaling, and that the septin structure surrounds the polar cap, ensuring that cell growth is directed toward the source of phersomone.
Journal ArticleDOI
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
Joshua B. Sheetz,Sebastian Mathea,Hanna Karvonen,Ketan Malhotra,Deep Chatterjee,Wilhelmiina Niininen,Robert Perttilä,Franziska Preuss,Franziska Preuss,Krishna Suresh,Steven Stayrook,Yuko Tsutsui,Ravi Radhakrishnan,Daniela Ungureanu,Stefan Knapp,Stefan Knapp,Mark A. Lemmon +16 more
TL;DR: Structures of all pseudokinase domains from the Wnt-binding receptor tyrosine kinases found that they share a conserved inactive conformation in their activation loop that resembles the autoinhibited insulin receptor kinase (IRK).
Journal ArticleDOI
Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway
Nambirajan Rangarajan,Claire Gordy,Lauren Askew,Samantha M. Bevill,Timothy C. Elston,Beverly Errede,Jillian H. Hurst,Joshua B. Kelley,Joshua B. Sheetz,Sara Kimiko Suzuki,Natalie H. Valentin,Everett Young,Henrik G. Dohlman +12 more
TL;DR: These findings point to the existence of a new and distinct branch of the pheromone-signaling pathway, one that likely leads to vacuolar engulfment of cytoplasmic proteins and recycling of cellular contents in preparation for mating.
Journal ArticleDOI
ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Fumin Shi,Jeannine M. Mendrola,Joshua B. Sheetz,Neo Z. Wu,Anselm Sommer,Kelsey F. Speer,Jasprina N. Noordermeer,Zhong-yuan Kan,Kay Perry,S. Walter Englander,Steven Stayrook,Steven Stayrook,Lee G. Fradkin,Lee G. Fradkin,Mark A. Lemmon +14 more
TL;DR: In this paper, crystal structures and WNT-binding characteristics of extracellular regions from the Drosophila ROR and RYK orthologs Nrk (neurospecific receptor tyrosine kinase) and Derailed-2 (Drl-2), which bind WNTs though a FZD-related cysteine-rich domain (CRD) and a WNTinhibitory factor (WIF) domain respectively.