J
Joshua Goldstein
Researcher at Lawrence Berkeley National Laboratory
Publications - 3
Citations - 4033
Joshua Goldstein is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Senescence & Cell culture. The author has an hindex of 3, co-authored 3 publications receiving 3374 citations.
Papers
More filters
Journal ArticleDOI
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.
Journal ArticleDOI
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Simona Parrinello,Enrique Samper,Ana Krtolica,Joshua Goldstein,Simon Melov,Judith Campisi,Judith Campisi +6 more
TL;DR: Oxygen sensitivity is identified as a critical difference between mouse and human cells, explaining their proliferative differences in culture, and possibly their different rates of cancer and ageing.
Journal ArticleDOI
Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models.
Joshua Goldstein,Francis Rodier,James C. Garbe,Martha R. Stampfer,Judith Campisi,Judith Campisi +5 more
TL;DR: It is shown that normal fibroblasts undergo very little apoptosis upon X‐irradiation, indicating dominance of the senescence response in this cell type, and apoptosis increased subtly but measurably when human mammary epithelial and skin fibroblast cells entered crisis, indicating that cell death during crisis is largely non‐apoptotic.