P
Pierre-Yves Desprez
Researcher at California Pacific Medical Center
Publications - 74
Citations - 13615
Pierre-Yves Desprez is an academic researcher from California Pacific Medical Center. The author has contributed to research in topics: Cancer & Senescence. The author has an hindex of 37, co-authored 65 publications receiving 10892 citations. Previous affiliations of Pierre-Yves Desprez include University of California & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
TL;DR: A senescence-associated secretory phenotype (SASP) is acquired that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
Journal ArticleDOI
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.
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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging.
TL;DR: It is shown that senescent human fibroblasts stimulate premalignant and malignant, but not normal, epithelial cells to proliferate in culture and form tumors in mice, suggesting it is an example of evolutionary antagonistic pleiotropy.
Journal ArticleDOI
Inflammatory Networks during Cellular Senescence: Causes and Consequences
Adam Freund,Arturo V. Orjalo,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +5 more
TL;DR: The secreted factors that make up the proinflammatory phenotype of senescent cells are listed and the impact of these factors on tissue homeostasis is described and the cellular pathways/processes known to regulate this phenotype are summarized.
Journal ArticleDOI
Senescent cells as a source of inflammatory factors for tumor progression
Albert R. Davalos,Jean-Philippe Coppe,Judith Campisi,Pierre-Yves Desprez,Pierre-Yves Desprez +4 more
TL;DR: The knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression is summarized.