Enrique Samper

TL;DR: Results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice.

TL;DR: Oxygen sensitivity is identified as a critical difference between mouse and human cells, explaining their proliferative differences in culture, and possibly their different rates of cancer and ageing.

TL;DR: It is reported here that mice bearing a disruption in the NF-ATc gene fail to develop normal cardiac valves and septa and die of circulatory failure before day 14.5 of development, indicating that the Ca2+/calcineurin/NF-atc signalling pathway is essential for normal cardiac valve and septum morphogenesis and hence, NF- ATc and its regulatory pathways are candidates for genetic defects underlying congenital human heart disease.

TL;DR: Conservation of the Notch pathway and its regulatory mechanisms from fly to mouse are demonstrated, and a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation is supported.

TL;DR: Results indicate that telomere shortening in mTR−/− mice leads to progressive loss of organismal viability.