J
Joshua J. White
Researcher at Erasmus University Rotterdam
Publications - 31
Citations - 1047
Joshua J. White is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Purkinje cell & Cerebellum. The author has an hindex of 13, co-authored 26 publications receiving 714 citations. Previous affiliations of Joshua J. White include Baylor College of Medicine & Erasmus University Medical Center.
Papers
More filters
Journal ArticleDOI
Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels
Vincenzo A. Gennarino,Vincenzo A. Gennarino,Ravi K. Singh,Joshua J. White,Joshua J. White,Antonia De Maio,Antonia De Maio,Kihoon Han,Kihoon Han,Ji-Yoen Kim,Ji-Yoen Kim,Paymaan Jafar-Nejad,Paymaan Jafar-Nejad,Alberto di Ronza,Alberto di Ronza,Hyojin Kang,Hyojin Kang,Layal S. Sayegh,Layal S. Sayegh,Thomas A. Cooper,Harry T. Orr,Roy V. Sillitoe,Huda Y. Zoghbi +22 more
TL;DR: Both increased wild-type ATAXIN1 levels and PUM1 haploinsufficiency could contribute to human neurodegeneration, demonstrating the importance of studying post-transcriptional regulation of disease-driving proteins to reveal factors underlying neurodegenersative disease.
Journal ArticleDOI
Development of the cerebellum: from gene expression patterns to circuit maps
Joshua J. White,Roy V. Sillitoe +1 more
TL;DR: The developmental mechanisms that coordinate the establishment of cerebellar structure and circuitry provide a powerful model for understanding how functional brain networks are formed and support the proper connectivity between incoming afferent projections and their target cells.
Journal ArticleDOI
Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice.
Joshua J. White,Roy V. Sillitoe +1 more
TL;DR: A neural mechanism by which olivocerebellar dysfunction promotes motor disease phenotypes is uncovered and the cerebellar nuclei are identified as a therapeutic target for surgical intervention.
Journal ArticleDOI
Cerebellar zonal patterning relies on Purkinje cell neurotransmission.
Joshua J. White,Marife Arancillo,Trace L. Stay,Nicholas A. George-Jones,Sabrina L. Levy,Detlef H. Heck,Roy V. Sillitoe +6 more
TL;DR: The results suggest that Purkinje cell inhibitory neurotransmission establishes the functional circuitry of the cerebellum by patterning the molecular zones, fine-tuning afferent circuitry, and shaping neuronal activity.
Journal ArticleDOI
In vivo analysis of Purkinje cell firing properties during postnatal mouse development.
TL;DR: It is shown that simple spike and complex spike firing develop with unique developmental trajectories throughout postnatal development, traversing several critical events that are required for circuit formation.