J
Josip Skoko
Researcher at University of Stuttgart
Publications - 3
Citations - 495
Josip Skoko is an academic researcher from University of Stuttgart. The author has contributed to research in topics: Wnt signaling pathway & Unfolded protein response. The author has an hindex of 2, co-authored 3 publications receiving 289 citations. Previous affiliations of Josip Skoko include University of Zagreb.
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Journal ArticleDOI
Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
Aitor Almanza,Antonio Carlesso,Chetan Chintha,Stuart Creedican,Dimitrios Doultsinos,Brian Leuzzi,Andreia Luís,Nicole McCarthy,Luigi Montibeller,Sanket More,Alexandra Papaioannou,Franziska Püschel,Maria Livia Sassano,Josip Skoko,Patrizia Agostinis,Jackie de Belleroche,Leif A. Eriksson,Simone Fulda,Adrienne M. Gorman,Sandra Healy,Andrey V. Kozlov,Cristina Muñoz-Pinedo,Markus Rehm,Eric Chevet,Afshin Samali +24 more
TL;DR: This review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology.
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Loss of p53 expression is accompanied by upregulation of beta-catenin in meningiomas: a concomitant reciprocal expression.
Nives Pećina-Šlaus,Anja Kafka,Tomislav Vladušić,Davor Tomas,Monika Logara,Josip Skoko,Reno Hrašćan +6 more
TL;DR: The findings provide novel information about p53 involvement in meningeal brain tumours and reveal the complex relationship between Wnt and p53 signalling, they suggest an important role for beta‐catenin in these tumours.
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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Christian T. Hellwig,M. Eugenia Delgado,M. Eugenia Delgado,Josip Skoko,Lydia Dyck,Carol Hanna,Alexa Wentges,Claudia Langlais,Cathrin Hagenlocher,Alexandra Mack,David Dinsdale,Kelvin Cain,Marion MacFarlane,Markus Rehm +13 more
TL;DR: In this paper, the authors showed that proteasome inhibition induces the formation of high molecular weight platforms in the cytosol that serve to activate caspase-8, and highlighted the crucial role of a ligand-independent but TRAIL-R2-dependent activation mechanism for Caspase8 in this scenario.