N
Nicole McCarthy
Researcher at Goethe University Frankfurt
Publications - 4
Citations - 503
Nicole McCarthy is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 3, co-authored 4 publications receiving 297 citations.
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Journal ArticleDOI
Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
Aitor Almanza,Antonio Carlesso,Chetan Chintha,Stuart Creedican,Dimitrios Doultsinos,Brian Leuzzi,Andreia Luís,Nicole McCarthy,Luigi Montibeller,Sanket More,Alexandra Papaioannou,Franziska Püschel,Maria Livia Sassano,Josip Skoko,Patrizia Agostinis,Jackie de Belleroche,Leif A. Eriksson,Simone Fulda,Adrienne M. Gorman,Sandra Healy,Andrey V. Kozlov,Cristina Muñoz-Pinedo,Markus Rehm,Eric Chevet,Afshin Samali +24 more
TL;DR: This review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology.
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Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress.
Behnaz Ahangarian Abhari,Nicole McCarthy,Marie Le Berre,Michelle Kilcoyne,Lokesh Joshi,Patrizia Agostinis,Simone Fulda,Simone Fulda +7 more
TL;DR: This study is the first to show that Smac mimetic protects from TM-triggered apoptosis by resolving the UPR and ER stress.
Journal ArticleDOI
The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells.
Nicole McCarthy,Nadezda Dolgikh,Susan E. Logue,John B. Patterson,Qinping Zeng,Adrienne M. Gorman,Afshin Samali,Simone Fulda,Simone Fulda +8 more
TL;DR: For the first time, the unfolded protein response is implicated in RMS biology and phenotype, and inhibition of UPR signalling reduces cell growth, suggesting that the UPR may be a promising target in R MS.
Journal ArticleDOI
NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis
TL;DR: It is reported that Smac mimetic-mediated activation of NF-κB contributes to the rescue of cancer cells from tunicamycin (TM)-triggered apoptosis.