J
Joy S. Xiang
Researcher at Stanford University
Publications - 10
Citations - 233
Joy S. Xiang is an academic researcher from Stanford University. The author has contributed to research in topics: RNA & Biology. The author has an hindex of 5, co-authored 6 publications receiving 172 citations.
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Journal ArticleDOI
High-throughput cellular RNA device engineering
TL;DR: A framework for engineering RNA devices from preexisting aptamers that exhibit ligand-responsive ribozyme tertiary interactions is described, which performed better in terms of gene silencing, activation ratio and ligand sensitivity than optimized RNA devices that rely on secondary-structure changes.
Posted ContentDOI
Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris
Nicholas Schaum,Jim Karkanias,Norma F. Neff,Andrew May,Tony Wyss-Coray,Spyros Darmanis,Joshua Batson,Botvinnik O,Michelle B. Chen,Chen S,Foad Green,Robert C. Jones,Ashley Maynard,Lolita Penland,Sit Rv,Geoff Stanley,James T. Webber,Fabio Zanini,Baghel As,Bakerman I,Bansal I,Daniela Berdnik,Biter Bilen,Douglas Brownfield,Cain C,Cho M,Cirolia G,Stephanie D. Conley,Demers A,Kubilay Demir,Kubilay Demir,Morree Ad,Divita T,Bois Hd,Dulgeroff Lbt,Ebadi H,F. H. Espinoza,Matt Fish,Matt Fish,Gan Q,Benson M. George,Astrid Gillich,Genetiano G,Xueying Gu,Gunsagar S. Gulati,Yan Hang,Shayan Hosseinzadeh,Huang A,Tal Iram,Taichi Isobe,Ives F,Kevin S. Kao,Karnam G,Aaron M. Kershner,Kiss B,Kong W,Maya E. Kumar,Jonathan Y. Lam,Davis P. Lee,Song Eun Lee,Gordon Li,Qi Li,Lin Liu,Lo A,Wan Jin Lu,Anoop Manjunath,May Kl,May Ol,McKay M,Ross J. Metzger,Marco Mignardi,Min D,Ahmad N. Nabhan,Katharine M. Ng,Joseph J. Noh,Patkar R,Weng Chuan Peng,Robert Puccinelli,Eric Rulifson,Shaheen S. Sikandar,Rahul Sinha,Krzysztof Szade,Krzysztof Szade,Tan W,Cristina M. Tato,Krissie Tellez,Kyle J. Travaglini,Carolina Tropini,Lucas M. Waldburger,Weele LJv,Wosczyna Mn,Joy S. Xiang,Shifeng Xue,Youngyunpipatkul J,Macy E. Zardeneta,Feijie Zhang,Lu Zhou,Castro P,Derek Croote,Joseph L. DeRisi,Angela Oliveira Pisco,Bernhard Kiss,Christin S. Kuo,Christin S. Kuo,Benoit Lehallier,Nguyen Pk,Serena Y. Tan,Bingying Wang,Hanadie Yousef,Philip A. Beachy,Chan Ckf,Kerwyn Casey Huang,Kenneth I. Weinberg,Sen Wu,Ben Anthony Barres,Michael F. Clarke,Seokho Kim,Mark A. Krasnow,Mark A. Krasnow,Norma F. Neff,Roel Nusse,Roel Nusse,Thomas A. Rando,Justin L. Sonnenburg,Wa Bm +124 more
TL;DR: A compendium of single cell transcriptome data from the model organism Mus musculus comprising more than 100,000 cells from 20 organs and tissues, which represent a new resource for cell biology, revealing gene expression in poorly characterized cell populations and allowing for direct and controlled comparison in cell types shared between tissues.
Journal ArticleDOI
Mammalian synthetic biology for studying the cell.
TL;DR: This study reviews synthetic biology tools that are being applied to effectively investigate diverse cellular processes, regulatory networks, and multicellular interactions and discusses current challenges and future developments in the field that may transform the types of investigation possible in cell biology.
Journal ArticleDOI
Massively parallel RNA device engineering in mammalian cells with RNA-Seq.
Joy S. Xiang,Matias Kaplan,Peter B. Dykstra,Michaela Hinks,Maureen McKeague,Christina D. Smolke +5 more
TL;DR: A quantitative, rapid and high-throughput mammalian cell-based RNA-Seq assay to efficiently engineer ribozyme switches that respond to theophylline, hypoxanthine, cyclic-di-GMP, and folinic acid from libraries of ~22,700 sequences in total are developed.
Journal ArticleDOI
A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors.
Brent Townshend,Joy S. Xiang,G. Manzanarez,Eric J. Hayden,Eric J. Hayden,Christina D. Smolke +5 more
TL;DR: In this paper, the de novo rapid in vitro evolution of RNA biosensors (DRIVER) enables multiplexed discovery of RNA sensors using aptamer-coupled ribozyme libraries.