D
Douglas Brownfield
Researcher at Harvard University
Publications - 18
Citations - 3975
Douglas Brownfield is an academic researcher from Harvard University. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 10, co-authored 14 publications receiving 2921 citations. Previous affiliations of Douglas Brownfield include University of California, Berkeley & Lawrence Berkeley National Laboratory.
Papers
More filters
Journal ArticleDOI
Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq
Barbara Treutlein,Douglas Brownfield,Angela Ruohao Wu,Norma F. Neff,Gary L. Mantalas,F. Hernan Espinoza,Tushar J. Desai,Mark A. Krasnow,Stephen R. Quake +8 more
TL;DR: The results confirmed the basic outlines of the classical model of epithelial cell-type diversity in the distal lung and led to the discovery of many previously unknown cell- type markers, including transcriptional regulators that discriminate between the different populations.
Journal ArticleDOI
Alveolar progenitor and stem cells in lung development, renewal and cancer
TL;DR: There is a switch after birth, when AT2 cells function as stem cells that contribute to alveolar renewal, repair and cancer, and it is proposed that local signals regulate AT2 stem-cell activity.
Journal ArticleDOI
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury
Andrew E. Vaughan,Alexis N. Brumwell,Ying Xi,Jeffrey E. Gotts,Douglas Brownfield,Barbara Treutlein,Kevin Tan,Victor M. Tan,Fengchun Liu,Mark R. Looney,Michael A. Matthay,Jason R. Rock,Harold A. Chapman +12 more
TL;DR: It is indicated that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the injury, and the outcomes of regeneration or fibrosis may depend in part on the dynamics of LNEP Notch signalling.
Journal ArticleDOI
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
Nicole Almanzar,Jane Antony,Ankit S. Baghel,Isaac Bakerman,Ishita Bansal,Ben A. Barres,Philip A. Beachy,Daniela Berdnik,Biter Bilen,Douglas Brownfield,Corey Cain,Charles Chan,Michelle B. Chen,Michael F. Clarke,Stephanie D. Conley,Spyros Darmanis,Aaron Demers,Kubilay Demir,Antoine de Morrée,Tessa Divita,Haley du Bois,Hamid Ebadi,F. Hernan Espinoza,Matt Fish,Qiang Gan,Benson M. George,Astrid Gillich,Rafael Gòmez-Sjöberg,Foad Green,Geraldine Genetiano,Xueying Gu,Gunsagar S. Gulati,Oliver Hahn,Michael S. Haney,Yan Hang,Lincoln Harris,Mu He,Shayan Hosseinzadeh,Albin Huang,Kerwyn Casey Huang,Tal Iram,Taichi Isobe,Feather Ives,Robert C. Jones,Kevin S. Kao,Jim Karkanias,Guruswamy Karnam,Andreas Keller,Aaron M. Kershner,Nathalie Khoury,Seung K. Kim,Bernhard M. Kiss,William Kong,Mark A. Krasnow,Maya E. Kumar,Christin S. Kuo,Jonathan K. Lam,Davis P. Lee,Song E. Lee,Benoit Lehallier,Olivia Leventhal,Guang Li,Qingyun Li,Ling Liu,Annie Lo,Wan Jin Lu,Maria F. Lugo-Fagundo,Anoop Manjunath,Andrew May,Ashley Maynard,Aaron McGeever,Marina McKay,M. Windy McNerney,Bryan D. Merrill,Ross J. Metzger,Marco Mignardi,Dullei Min,Ahmad N. Nabhan,Norma Neff,Katharine M. Ng,Patricia K. Nguyen,Joseph Noh,Roel Nusse,Róbert Pálovics,Rasika Patkar,Weng Chuan Peng,Lolita Penland,Angela Oliveira Pisco,Katherine S. Pollard,Robert Puccinelli,Zhen Qi,Stephen R. Quake,Thomas A. Rando,Eric J. Rulifson,Nicholas Schaum,Joe M. Segal,Shaheen S. Sikandar,Rahul Sinha,Rene V. Sit,Justin L. Sonnenburg,Daniel Staehli,Krzysztof Szade,Michelle Tan,Weilun Tan,Cristina M. Tato,Krissie Tellez,Laughing Bear Torrez Dulgeroff,Kyle J. Travaglini,Carolina Tropini,Margaret Tsui,Lucas M. Waldburger,Bruce Wang,Linda J. van Weele,Kenneth I. Weinberg,Irving L. Weissman,Michael N. Wosczyna,Sean M. Wu,Tony Wyss-Coray,Jinyi Xiang,Soso Xue,Kevin A. Yamauchi,Andrew C. Yang,Lakshmi P. Yerra,Justin Youngyunpipatkul,Brian Yu,Fabio Zanini,Macy E. Zardeneta,Alexander Zee,Chunyu Zhao,Fan Zhang,Hui Zhang,Martin J. Zhang,Lu Zhou,James Zou +133 more
Journal ArticleDOI
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells
TL;DR: It is shown that the rare AT2 lung stem cells have a special niche next to a fibroblast secreting Wnts, and many of them are near single, Wnt-expressing fibroblasts, which maintains the gas exchange surface and is coopted in cancer.