M
Manuel de la Mata
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 19
Citations - 3057
Manuel de la Mata is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 14, co-authored 18 publications receiving 2840 citations. Previous affiliations of Manuel de la Mata include National University of Cordoba & Friedrich Miescher Institute for Biomedical Research.
Papers
More filters
Journal ArticleDOI
A Slow RNA Polymerase II Affects Alternative Splicing In Vivo
Manuel de la Mata,Claudio R. Alonso,Sebastian Kadener,Juan Pablo Fededa,Matías Blaustein,Federico Pelisch,Paula Cramer,David Bentley,Alberto R. Kornblihtt +8 more
TL;DR: It is shown that expression of a human equivalent to Drosophila's C4 pol II in human cultured cells affects alternative splicing of the fibronectin EDI exon and adenovirus E1a pre-mRNA and resplices of the Hox gene Ultrabithorax are stimulated, which demonstrates the transcriptional control ofAlternative splicing on an endogenous gene.
Journal ArticleDOI
Multiple links between transcription and splicing
TL;DR: The presence of transcription factors in the spliceosome and the existence of proteins with dual activities in splicing and transcription can explain the links between both processes and add a new level of complexity to the regulation of gene expression in eukaryotes.
Journal ArticleDOI
Control of alternative splicing through siRNA-mediated transcriptional gene silencing.
Mariano Alló,Valeria Buggiano,Juan Pablo Fededa,Ezequiel Petrillo,Ignacio E. Schor,Manuel de la Mata,Eneritz Agirre,Mireya Plass,Eduardo Eyras,Sherif Abou Elela,Roscoe Klinck,Benoit Chabot,Alberto R. Kornblihtt +12 more
TL;DR: It is shown that siRNAs targeting intronic or exonic sequences close to an alternative exon regulate the splicing of that exon in hepatoma and HeLa cells with siRNA antisense strands designed to enter the silencing pathway.
Journal ArticleDOI
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.
Manuel J. Muñoz,M. Soledad Pérez Santangelo,Maria Paola Paronetto,Manuel de la Mata,Federico Pelisch,Stéphanie Boireau,Kira Glover-Cutter,Claudia Ben-Dov,Matías Blaustein,Juan José Lozano,Gregory H. Bird,David Bentley,Edouard Bertrand,Alberto R. Kornblihtt +13 more
TL;DR: It is shown that ultraviolet irradiation affects cotranscriptional AS in a p53-independent way, through the hyperphosphorylation of RNA polymerase II carboxy-terminal domain (CTD) and a subsequent inhibition of transcriptional elongation, estimated in vivo and in real time.
Journal ArticleDOI
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20
TL;DR: It is found that the CTD is required for the inhibitory action of the serine/arginine-rich protein SRp20 on the inclusion of a fibronectin cassette exon in the mature mRNA.